Calorimetric investigation of the interaction between α,β-poly(N-hydroxyethyl)-dl-aspartamide and surfactants

Giammona, Gaetano; Carlisi, Bianca; Cavallaro, Gennara; Donato, I. D.; Pinio, F.; Liveri, Vincenzo Turco

doi:10.1016/0378-5173(90)90275-9

Cited by 18 publications

(5 citation statements)

References 10 publications

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“…Polyaspartamide is a water-soluble, biocompatible synthetic polymer with a protein-like structure that is understood as a plasma extender and polymeric carrier in drug delivery because it is nontoxic or no antigenic, degradable in living systems and modified easily by reactions with the side chain (Giammona et al, 1987(Giammona et al, , 1990(Giammona et al, , 1991. As reported, antiviral drugs and anti-inflammatory agents were covalently linked to poly-␣,␤-[N-(2-hydroxyethyl)-d,l-aspartamide] (PHEA) forming drug-polymer conjugates capable of increasing drug stability and bioavailility.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin-containing polyaspartamide gadolinium complexes as potential magnetic resonance imaging contrast agents

Yan

et al. 2011

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Porphyrin-containing polyaspartamide gadolinium complexes as potential magnetic resonance imaging contrast agents

Yan

et al. 2011

International Journal of Pharmaceutics

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“…Polyaspartamide is a water-soluble, biologically well-tolerated synthetic polymer with a protein-like structure that was used as a plasma extender and a drug carrier because it is nontoxic, nonantigenic, and degradable in living systems and modified readily by the reaction with the side chain ( , ). As reported, antiviral drugs and antiinflammatory agents were covalently linked to poly-α,β-[ N -(2-hydroxyethyl)- d , l -aspartamide] (PHEA) forming drug−polymer conjugates capable of increasing drug stability and bioavailility.…”

Section: Introductionmentioning

confidence: 99%

Polyaspartamide Gadolinium Complexes Containing Sulfadiazine Groups as Potential Macromolecular MRI Contrast Agents

Yan

Liu

2005

Bioconjugate Chem.

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Both diethylenetriaminepentaacetic acid (DTPA) and sulfadiazine (SD) were incorporated into polyaspartamides with different side chains, including poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA), poly-alpha,beta-[N- (3-hydroxypropyl)-L-aspartamide] (PHPA), poly-alpha,beta-[N-(2-aminoethy1)-L-aspartamide] (PAEA), poly-alpha,beta-[N-(4-aminobuty1)-L-aspartamide] (PABA), and poly-alpha,beta-[N-(6-aminohexyl)-L-aspartamide] (PAHA). The polyaspartamide ligands containing DTPA and SD groups were further reacted with gadolinium chloride to give the corresponding macromolecular gadolinium complexes. Experimental data of 1H NMR, IR, UV, and elemental analysis exhibited the formation of the polyaspartamide ligands and gadolinium complexes. Relaxivity studies indicated that the macromolecular chelates possess higher relaxivities than that of the clinically used Gd-DTPA. MR imaging showed that the macromolecular chelate PAEA-Gd-DTPA-SD greatly enhanced the contrast of MR images of hepatoma in the lower limb of mice and provided prolonged intravascular duration. Thus the polyaspartamide gadolinium complex containing SD groups is expected to be used as the potential macromolecular MRI contrast agents for hepatoma in mice.

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“…It can be modified easily by reactions with the side chains. As reported, antiviral drugs and anti‐inflammatory agents were covalently linked to poly‐α,β‐[ N ‐(2‐hydroxyethyl)‐ D , L ‐aspartamide] (PHEA) forming drug–polymer conjugates capable of increasing drug stability and bioavailability 7–13. Equally, poly(β‐benzyl‐ L ‐aspartate) (PBLA) can be used as the hydrophobic segment 5, 6…”

Section: Introductionmentioning

confidence: 99%

Preparation, properties, and mathematical modeling of microparticle drug delivery systems based on biodegradable amphiphilic triblock copolymers

Yan

Cheng

et al. 2004

J of Applied Polymer Sci

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A series of biodegradable amphiphilic A-B-A type triblock copolymers P(BLA-PEG-BLA), composed of hydrophilic poly(ethylene glycol) (PEG) as a middle block component (B) and hydrophobic poly(␤-benzyl-l-aspartate) as outer polypeptide block components (A), were synthesized by copolymerization of ␤-benzyl-l-aspartate N-carboxy anhydride (BLA-NCA) and the diaminated PEG with the primary amino groups capped at both ends. These P(BLA-PEG-BLA) copolymers were characterized by 1 H-NMR, DSC, and GPC. The triblock copolymers were used to prepare three kinds of drug delivery systems including Norfloxacin (INN)-incorporated P(BLA-PEG-BLA) microparticles and tablets. The morphologies of the microparticles were characterized by SEM. The in vitro release properties of the microparticles and tablets in PBS were also evaluated. A mathematical model, which incorporates a linear first-order dissolution term and the transient Fickian diffusion equation, was developed to account for the kinetics of drug release from the INN-incorporated P(BLA-PEG-BLA) microparticles. The results indicated that the overall release process was well controlled by both drug dissolution and diffusion.

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Calorimetric investigation of the interaction between α,β-poly(N-hydroxyethyl)-dl-aspartamide and surfactants

Cited by 18 publications

References 10 publications

Porphyrin-containing polyaspartamide gadolinium complexes as potential magnetic resonance imaging contrast agents

Porphyrin-containing polyaspartamide gadolinium complexes as potential magnetic resonance imaging contrast agents

Polyaspartamide Gadolinium Complexes Containing Sulfadiazine Groups as Potential Macromolecular MRI Contrast Agents

Preparation, properties, and mathematical modeling of microparticle drug delivery systems based on biodegradable amphiphilic triblock copolymers

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