Calorimetric Approaches to Characterizing Undesired Reactions

Roth, Megan

doi:10.1002/9781119600800.ch4

Cited by 1 publication

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accelerating rate calorimetry (ARC) can be used to provide the desired pressure generation information and give a more accurate onset decomposition temperature. 9 In this technique, 3−5 g of material is placed in a spherical test cell connected to a pressure transducer. The sample is heated in a series of steps until exothermic activity is detected.…”

Section: Methodsmentioning

confidence: 99%

“…DSC is a screening tool and provides a guide; it also has the important limitation of being unable to measure any gas/pressure generation from a thermal decomposition. Accelerating rate calorimetry (ARC) can be used to provide the desired pressure generation information and give a more accurate onset decomposition temperature . In this technique, 3–5 g of material is placed in a spherical test cell connected to a pressure transducer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies

et al. 2020

View full text Add to dashboard Cite

Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An introduction to process safety and a series of case studies illustrating how safety is routinely considered within the pharmaceutical industry is presented. The concepts presented herein are applicable to multiple industries, academic research, and chemical reactions conducted on all scales. The case studies include examples where a synthesis was redesigned to afford a triazole intermediate without forming potentially explosive byproducts, an exothermic reaction was controlled by understanding the heat output with time and developing a portion-wise addition procedure, and a reaction that displayed extremely fast gas evolution was managed by using an alternative solvent and controlling the rate of reagent addition.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%