Calorie restriction modifies the delayed-type hypersensitivity response to the hapten trinitrobenzenesulfonic acid and to hapten-modified syngeneic spleen cells

Pocino, M; Baute, L.; Malavé, Inés

doi:10.1016/0008-8749(87)90310-8

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Regulatory cell changes may well be involved, but their nature is not clear. Although, as observed by others (2,12), the thymus and spleen became atrophic and contact sensitivity disappeared, proliferation of splenocytes in response to mitogens and allogeneic cells was only slightly affected by the low-protein diet. Rather than depression of responses we saw an increase in proliferation after exposure to lipopolysaccharide (a nonspecific B-cell mitogen) or allogeneic cells (a specific T-cell stimulus).…”

supporting

confidence: 59%

Sendai virus infection of mice with protein malnutrition

Peña‐Cruz

Reiss

McIntosh

1989

J Virol

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supporting

confidence: 59%

Sendai virus infection of mice with protein malnutrition

Peña‐Cruz

Reiss

McIntosh

1989

J Virol

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“…Protein‐restricted diets have also been shown to suppress and shorten the immune response (Jose & Good 1973; Ing et al. 2000), while calorie‐restricted diets can reduce delayed‐type hypersensitivity responses (Pocino et al. 1987).…”

Section: Introductionmentioning

confidence: 99%

“…For example, mice infected with the nematode Heligmosomoides polygyrus that were fed on energy (but not protein)restricted diets had suppressed humoral and cellular immune responses compared with normally fed controls (Koski et al 1999). Protein-restricted diets have also been shown to suppress and shorten the immune response (Jose & Good 1973;Ing et al 2000), while calorie-restricted diets can reduce delayed-type hypersensitivity responses (Pocino et al 1987). However, there also appear to be some positive effects of impoverished diets on immune function, particularly cellular immune responses.…”

Section: Introductionmentioning

confidence: 99%

Measures of immune function of wild mice, Mus musculus

et al. 2010

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The immune function of wild animals has been rather little studied. Wild animals' immune function may differ from that of laboratory bred animals because of their different environments. This idea follows from the concept of resource partitioning in which animals distribute scarce resources to all aspects of life, including to costly immune responses. A logical extension of this idea is that there may be substantial interindividual variation in the immune function of wild animals. To begin to investigate this, we compared the immune function of a laboratory bred mouse strain (C57BL/6, a widely used mouse strain that makes potent immune responses) and wild caught Mus musculus. We found that by most measures of immune function, the wild caught mice had greater immune function. Specifically, wild mice had greater concentrations and more avid antigen-specific IgG responses, as well as higher concentrations of total IgG and IgE, compared with those laboratory bred mice. Moreover, flow cytometric analysis showed a comparatively greater overall level of activation of the cells of the immune system in wild mice. Lastly, we observed that immune function was substantially more variable among wild caught mice than among the laboratory bred mice. The next research challenge is to understand which aspects of an individual animal's life determine its immune function.

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“…The immunological memory and spleen-derived antibody-producing B cells were also reduced in food-restricted deer mice (Martin et al, 2007(Martin et al, , 2008. In addition, food restriction decreased mitogen-induced T-cell proliferation and humoral immunity in mice (Pocino et al, 1987;Rogers et al, 2008;Ishikawa et al, 2009). However, other researchers obtained different findings in which immune responses were enhanced by food or caloric restriction (Pahlavani, 2000;Jolly, 2004;Ritz and Gardner, 2006;Ahmed et al, 2009;Zysling et al, 2009;Berger, 2013).…”

Section: Introductionmentioning

confidence: 93%

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

Tian

2017

Journal of Experimental Biology

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Small mammals in temperate areas face seasonal fluctuations of temperature and food availability, both of which may influence their immune responses, which are critical to survival. In the present study, we tested the hypothesis that low temperature and food restriction suppress immune function in striped hamsters (Cricetulus barabensis). Thirty-seven adult male hamsters were randomly assigned to warm (23±1°C) and cold (5±1°C) treatment groups, which were further divided into fed and food-restricted groups. Body mass was not affected by cold stress, food restriction or the interaction cold stress×food restriction. Cold stress decreased total body fat mass, haematological parameters including white blood cells, lymphocytes and neutrophilic granulocytes, and immunoglobin (Ig) M titres 5 days after injecting keyhole limpet haemocyanin (KLH). However, cold temperature increased bacterial killing capacity, indicative of innate immunity, and did not affect the mass of the thymus and spleen, intermediate granulocytes, the phytohaemagglutinin (PHA) response and the levels of blood glucose and serum leptin. Corticosterone concentration was affected significantly by the interaction cold stress×food restriction but not by cold stress or food restriction alone. Food restriction reduced thymus mass, but other immunological parameters including body fat mass, spleen mass, haematological parameters, innate immunity, PHA response, the titres of IgM and IgG, and the levels of blood glucose and serum leptin were all not affected by food restriction or the interaction cold stress×food restriction. Innate immunity was positively correlated with leptin levels, whereas no significant correlations were observed in the levels of blood glucose, serum leptin, corticosterone and all the detected immune parameters. Our results show that cold stress suppressed humoral immunity but enhanced innate immunity and did not affect cellular immunity in striped hamsters. Most immunological indices were not influenced by food restriction. Blood glucose, leptin and corticosterone could not explain the changes of innate, cellular and humoral immunity upon cold stress or food restriction in striped hamsters.

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Calorie restriction modifies the delayed-type hypersensitivity response to the hapten trinitrobenzenesulfonic acid and to hapten-modified syngeneic spleen cells

Cited by 9 publications

References 23 publications

Sendai virus infection of mice with protein malnutrition

Sendai virus infection of mice with protein malnutrition

Measures of immune function of wild mice, Mus musculus

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

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