Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy

David, Cícera Edna Barbosa; Lucas, Aline Maria Brito; Cunha, Pedro Lourenzo Oliveira; Viana, Yuana Ivia Ponte; Yoshinaga, Marcos Y.; Miyamoto, Sayuri; Filho, Adriano B. Chaves; Varela, Anna Lídia Nunes; Kowaltowski, Alicia J.; Facundo, Heberty T.

doi:10.1007/s13105-021-00863-4

Cited by 4 publications

(2 citation statements)

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“…In an isoproterenol-induced cardiac hypertrophy model, CR protected against alterations in the cardiac lipidome, mitochondrial disturbances, and oxidative stress. [22] In a mouse model of chronic hypertensive cardiac remodeling, a carbohydrate-restricted diet with a high percentage of fat or protein mitigated the progression of hypertrophy. Specifically, the high-fat, low-carbohydrate (Fat-LC) diet upregulated ketone body levels and inhibited the mammalian target of rapamycin (mTOR) signaling pathway, while the high-protein, low-carbohydrate (Pro-LC) diet activated glycogen synthase kinase (GSK)-3β.…”

Section: Beneficial Effects Of Cr On the Cardiovascular Systemmentioning

confidence: 99%

Caloric restriction, Sirtuins, and cardiovascular diseases

Wei,

Yang,

Wang

et al. 2024

Chinese Medical Journal

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Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, have emerged as key regulators of cellular metabolism, stress responses, and the aging process, serving as energy status sensors in response to CR. However, the mechanism through which CR regulates Sirtuin function to ameliorate cardiovascular disease remains unclear. In this review, we provide an overview of recent research investigating the interplay between Sirtuins and CR, specifically focusing on their potential implications for cardiovascular health. We provide a comprehensive summary of the benefits of CR for the cardiovascular system mediated directly via Sirtuins. CR has also been shown to have considerable impact on specific metabolic organs, leading to the production of small molecules that enter systemic circulation and subsequently regulate Sirtuin activity within the cardiovascular system. The direct and indirect effects of CR offer a potential mechanism for Sirtuin modulation and subsequent cardiovascular protection. Understanding the interplay between CR and Sirtuins will provide new insights for the development of interventions to prevent and treat cardiovascular diseases.

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Section: Beneficial Effects Of Cr On the Cardiovascular Systemmentioning

confidence: 99%

Caloric restriction, Sirtuins, and cardiovascular diseases

Wei,

Yang,

Wang

et al. 2024

Chinese Medical Journal

View full text Add to dashboard Cite

show abstract

“…Beyond these effects, CR enhances tissue resilience, especially in muscle tissues. 8 , 9 In rodent skeletal muscle, CR promotes expansion of muscle stem cells, referred to as satellite cells, after short-term (3-month) CR. 8 , 10 , 11 There are emerging hypotheses suggesting that the beneficial effects of CR are mediated via the release of therapeutic secretory factors.…”

Section: Introductionmentioning

confidence: 99%