Caloric Restriction and Antiaging Effects

Xiang, Lan; He, Guoqing

doi:10.1159/000323748

Cited by 26 publications

(14 citation statements)

References 158 publications

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“…Such findings have laid the foundation for intensive investigations of DR and its associated mechanisms, along with efforts to develop DR mimetic pharmaceuticals and studies for evaluating long-term effects of DR in rhesus monkeys and humans (Ingram et al, 2006; Holloszy and Fontana, 2007; Colman et al, 2009). The conserved character of the DR response and its consistent effects on lifespan has often been emphasized (Cantó and Auwerx, 2009;Anderson and Weindruch, 2010;Omodei and Fontana, 2011; Xiang and He, 2011). To support this idea, abundant evidence is available from survival experiments using laboratory rodents (Weindruch and Walford, 1988; Turturro et al, 1999), and DR protocols have also been shown to increase the lifespan of diverse invertebrate species (Austad, 1989; Partridge et al, 2005; Kaeberlein et al, 2006; Lee et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell

2012

Ageing Research Reviews

194

176

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Laboratory survival experiments have shown that dietary restriction (DR) can increase median and maximum lifespan. This paper provides a meta-analysis of laboratory experiments that have evaluated the effects of DR on lifespan in rats and mice (1934 – present). In rats, DR increased median lifespan by 14 – 45% in half of all experiments, but in mice the effects of DR have been much weaker (4 – 27%). The least favorable effects of DR on lifespan have been observed among inbred rather than non-inbred mouse strains. In fact, some inbred mouse strains do not necessarily live longer with DR, including DBA/2 male mice and several strains from the ILSXISS recombinant inbred panel. Shortening of lifespan with DR has also been observed and confirmed for ILSXISS strain 114. Importantly, all rodent studies may be biased by the effects of laboratory breeding, since one study has shown that median lifespan is not improved by DR in wild-derived mice. These findings suggest that the set of genetic backgrounds studied in rodent DR experiments should be diversified. This will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species.

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Section: Introductionmentioning

confidence: 99%

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell

2012

Ageing Research Reviews

194

176

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“…CR also induces a range of beneficial health benefits in many organisms including humans (Mercken et al ., 2013), and it would appear, in some instances, that significant health benefits can exist without lifespan extension (Selman, 2014). While the effects of CR on lifespan and healthspan have been known for nearly a century, the precise molecular mechanisms underlying these effects remain unknown, although a whole range of putative mechanisms have been proposed (Anderson & Weindruch, 2010; Xiang & He, 2011). For example, oxidative damage to biomolecules has been suggested as being a key mechanism underlying aging (Gredilla & Barja, 2005; Naudí et al ., 2013), and that CR may act by directly reducing molecular oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

et al. 2014

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Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles. In this study, we employ a liquid chromatography quadrupole time-of-flight-based methodology to demonstrate that CR in the liver of male C57BL/6 mice: (i) induces marked changes in the cellular lipidome, (ii) specifically reduces levels of a phospholipid peroxidation product, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphatidylcholine, (iii) alters cellular phosphoethanolamine and triglyceride distributional profiles, (iv) affects mitochondrial electron transport chain complexes, increasing complex II and decreasing complex III and (v) is associated with specific changes in liver metabolic pathways. These data demonstrate that CR induces a specific lipidome and metabolome reprogramming event in mouse liver which is associated with lower protein oxidative damage, as assessed by mass spectrometry-based measurements. Such changes may be critical to the increased lifespan and healthspan observed in C57BL/6 mice following CR.

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“…Traditionally, this approach served primarily to early detect growth faltering as a marker of the presence of infectious and other diseases, or of inadequate nutrition, which show particularly rapid adverse effects on growth in infancy and early childhood [1]. More recently, however, the impact of excessive growth on child health has been receiving increasing attention [2][3][4].…”

mentioning

confidence: 99%

Early Influences of Nutrition on Postnatal Growth

Koletzko¹,

Beyer²,

Brands³

et al. 2013

Nestlé Nutrition Institute Workshop Series

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Health and nutrition modulate postnatal growth. The availability of amino acids and energy, and insulin and insulin-like growth factor-I (IGF-I) regulates early growth through the mTOR pathway. Amino acids and glucose also stimulate the secretion of IGF-I and insulin. Postnatal growth induces lasting, programming effects on later body size and adiposity in animals and in human observational studies. Rapid weight gain in infancy and the first 2 years was shown to predict increased obesity risk in childhood and adulthood. Breastfeeding leads to lesser high weight gain in infancy and reduces obesity risk in later life by about 20%, presumably partly due to the lower protein supply with human milk than conventional infant formula. In a large randomized clinical trial, we tested the hypothesis that reduced infant formula protein contents lower insulin-releasing amino acid concentrations and thereby decrease circulating insulin and IGF-I levels, resulting in lesser early weight gain and reduced later obesity risk (the 'Early Protein Hypothesis'). The results demonstrate that lowered protein in infant formula induces similar -but not equal -metabolic and endocrine responses and normalizes weight and BMI relative to breastfed controls at the age of 2 years. The results available should lead to enhanced efforts to actively promote, protect and support breastfeeding. For infants that are not breastfed or not fully breastfed, the use of infant formulas with lower protein contents but high protein quality appears preferable. Cows' milk as a drink provides high protein intake and should be avoided in infancy.

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Caloric Restriction and Antiaging Effects

Cited by 26 publications

References 158 publications

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

Early Influences of Nutrition on Postnatal Growth

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