Calmodulin physically interacts with the erythropoietin receptor and enhances Jak2-mediated signaling

Kakihana, Kazuhiko; Yamamoto, Masahide; Iiyama, Mitsuko; Miura, Osamu

doi:10.1016/j.bbrc.2005.07.095

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…We have already discussed the potential influence of cross-talk with the Wnt/β-catenin pathway in influencing downstream effects of EPO in microglial cells. Another example is the calcium channel, TRPC2 ( 102 , 103 ), which facilitates calmodulin-dependent enhancement of EpoR-associated JAK2 signaling in erythroid progenitor cells ( 104 ). TRPC2 channels are also expressed in the CNS and expression may vary between cell types, which could also contribute to cell type specific responses to EPO ( 105 , 106 ).…”

Section: Epo Signaling May Be Cell Type and Context Dependentmentioning

confidence: 99%

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia

Bond

Rex

2014

Front. Immunol.

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Neuroinflammation is a normal and healthy response to neuronal damage. However, excessive or chronic neuroinflammation exacerbates neurodegeneration after trauma and in progressive diseases such as Alzheimer’s, Parkinson’s, age-related macular degeneration, and glaucoma. Therefore, molecules that modulate neuroinflammation are candidates as neuroprotective agents. Erythropoietin (EPO) is a known neuroprotective agent that indirectly attenuates neuroinflammation, in part, by inhibiting neuronal apoptosis. In this review, we provide evidence that EPO also modulates neuroinflammation upstream of apoptosis by acting directly on glia. Further, the signaling induced by EPO may differ depending on cell type and context possibly as a result of activation of different receptors. While significant progress has been made in our understanding of EPO signaling, this review also identifies areas for future study in terms of the role of EPO in modulating neuroinflammation.

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Section: Epo Signaling May Be Cell Type and Context Dependentmentioning

confidence: 99%

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia

Bond

Rex

2014

Front. Immunol.

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Erythropoietin-loaded oligochitosan nanoparticles for treatment of periventricular leukomalacia

Wang¹,

Hu²,

Leach³

et al. 2012

International Journal of Pharmaceutics

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Proteomic Analysis of the Effects of Tetramethylpyrazine on Irradiated QXMSC1 Cells

Xiao

Wang

et al. 2007

Biological & Pharmaceutical Bulletin

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Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes of cellular and molecular response of tetramethylpyrazine to irradiation damage, we comparatively analyzed the proteome of nonirradiated, irradiated and tetramethylpyrazine treated QXMSC1 cells. Reverse transcriptase polymerase chain reaction (RT-PCR) were used to validate the differentially expressed proteins. 20 Gy 60 Co g g irradition inhibited QMSC1 cells growth and tetramethylpyrazine could reverse of this action due to stimulating QXMSC1 cells from G 1 to S progression. Proteomic analytical results showed that 18 spots were changed in irradiated QXMSC1 cells, and 15 spots matched with known proteins after database searching. The expression level of proteins such as translationally controlled tumor protein (TCTP), and galectin-3, were increased in irradiated QXMSC1 cells, while calmodulin, pyruvate kinase were decreased. Tetramethylpyrazine could prevent this change or reverse to some degree. The function of these proteins involves in hematopoiesis, cell cycle and signal transduction. The changes of these proteins were confirmed by RT-PCR at mRNA levels. This study suggested that stimulating proliferation via tetramethylpyrazine played an important role in the cure effect on irradiated QXMSC1 cells and was helpful to deeply understand the mechanism of tetramethylpyrazine at the molecular level.

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Calmodulin physically interacts with the erythropoietin receptor and enhances Jak2-mediated signaling

Cited by 3 publications

References 31 publications

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia

Erythropoietin-loaded oligochitosan nanoparticles for treatment of periventricular leukomalacia

Proteomic Analysis of the Effects of Tetramethylpyrazine on Irradiated QXMSC1 Cells

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