Calmodulin inhibitors suppress calcium signaling from serotonin receptors in smooth muscle cells and abolish vasoconstrictive response on intravenous introduction of serotonin

Кожевникова, Л. М.; Zharkikh, Irina; Avdonin, P. V.

doi:10.1134/s1062359013040080

Cited by 1 publication

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Arabidopsis , CAMTA proteins are proposed to be regulated by one or more of the six calmodulin (CaM) proteins and putatively act as a point of integration of calcium (Ca 2+ )‐CaM signaling pathway with the cold signaling pathway . In animal cells, the role of melatonin and its precursor serotonin, as modulators of Ca 2+ ‐CaM signaling is well documented . Melatonin can directly bind to CaM to regulate several physiological functions such as the cytoskeletal effects involving membrane receptors .…”

Section: Discussionmentioning

confidence: 99%

Role of melatonin in alleviating cold stress in Arabidopsis thaliana

Bajwa

Shukla

Sherif

et al. 2014

Journal of Pineal Research

369

264

View full text Add to dashboard Cite

Melatonin (N-acetyl-5-methoxytryptamine) has been implicated in abiotic and biotic stress tolerance in plants. However, information on the effects of melatonin in cold-stress tolerance in vivo is limited. In this study, the effect of melatonin was investigated in the model plant Arabidopsis thaliana challenged with a cold stress at 4⁰C for 72 and 120 hr. Melatonin-treated plants (10 and 30 μm) had significantly higher fresh weight, primary root length, and shoot height compared with the nontreated plants. To aid in the understanding of the role of melatonin in alleviating cold stress, we investigated the effects of melatonin treatment on the expression of cold-related genes. Melatonin up-regulated the expression of C-repeat-binding factors (CBFs)/Drought Response Element Binding factors (DREBs), a cold-responsive gene, COR15a, a transcription factor involved in freezing and drought-stress tolerance CAMTA1 and transcription activators of reactive oxygen species (ROS)-related antioxidant genes, ZAT10 and ZAT12, following cold stress. The up-regulation of cold signaling genes by melatonin may stimulate the biosynthesis of cold-protecting compounds and contribute to the increased growth of plants treated with exogenous melatonin under cold stress.

show abstract

Section: Discussionmentioning

confidence: 99%