Calmodulin‐dependent cyclic nucleotide phosphodiesterase activity is altered by 20 μT magnetostatic fields

Liboff, Abraham R.; Cherng, Shen; Jenrow, Kenneth A.; Bull, Arthur W.

doi:10.1002/bem.10063

Cited by 64 publications

(44 citation statements)

References 12 publications

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“…Results obtained in the present investigation supports the earlier observations, which had reported the occurrence of oxidative/nitrosative stress in response to the MF exposure (Li and Chow 2000;Noda et al 2000;Kabuto et al 2001;Lee et al 2004), including effects on cell signaling processes (Liboff et al 2003;Zhang et al 2010) and carcinogenic effects (Bayazit et al 2010). Previous studies suggest that static and time-varying electric and MFs exposure caused oxidative DNA damage (Ivancsits et al 2003;Yokus et al 2005), increased plasma, liver, lung and kidney TBARS and SOD levels (Harakawa et al 2005;Guler (Jelenkovic et al 2005;Di Loreto et al 2009) altered cell proliferation , cortical serotonergic neurotransmission (Janac et al 2009) and memory impair (Jadidi et al 2007) in various biological organisms.…”

Section: Discussionsupporting

confidence: 92%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

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Abstract. The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 µT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum > hippocampus > cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus > cerebellum > cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 µT than at 50 µT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions.

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Section: Discussionsupporting

confidence: 92%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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“…Furthermore, numerous studies have explored the interaction of man-made static and alternating magnetic fields with biological systems. Previous research showed that these magnetic fields can induce changes in behavior (Rudolph et al, 1985;Prato et al, 1996;Janac et al, 2005), enzyme activity (Nossol et al, 1993;Blank and Soo, 1996;Liboff et al, 2003;Chen et al, 2009), the synthesis and release of neurohormons (Peric-Mataruga et al, 2008), biophysical properties of neurons (McLean et al, 1995;Calvo and Azanza, 1999;Ye et al, 2004;Todorovic et al, 2007), synaptic transmission (Rosen, 1992) and ion channel currents (Shen et al, 2007). Furthermore, magnetic field influence on nucleic acids and protein synthesis has been found (Cridland et al, 1999;Ciombor et al, 2002;Hirai et al, 2002;Schmitz et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of alternating the magnetic feld on phosphate metabolism in the nervous system of Helix pomatia

Nikolić¹,

Rokic²,

Todorović³

et al. 2010

Biol. Res.

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The effect of extremely low frequency magnetic fields (50 Hz, 0.5 mT) -ELF-MF, on phosphate metabolism has been studied in the isolated ganglions of the garden snail Helix pomatia, after 7 and 16 days of snail exposure to ELF-MF. The influence of ELF-MF on the level of phosphate compounds and intracellular pH was monitored by 31 P NMR spectroscopy. Furthermore, the activity of enzymes involved in phosphate turnover, total ATPases, Na + /K + -ATPase and acid phosphatase has been measured. The exposure of snails to the ELF-MF for the period of 7 days shifted intracellular pH toward more alkaline conditions, and increased the activity of investigated enzymes. Prolonged exposure to the ELF-MF for the period of 16 days caused a decrease of PCr and ATP levels and decreased enzyme activity, compared to the 7-day treatment group. Our results can be explained in terms of: 1. increase in phosphate turnover by exposure to the ELF-MF for the period of 7 days, and 2. adaptation of phosphate metabolism in the nervous system of snails to prolonged ELF-MF exposure.

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“…In most cellular models the ELF-EMF-induced effects are found in the intracellular calcium variations [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute and Chronic Low Frequency Electromagnetic Field Exposure on PC12 Cells during Neuronal Differentiation

Morabito

Guarnieri

Fanò³

et al. 2010

Cell Physiol Biochem

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Background/Aims. The purpose of this study was to provide information about the in vitro neuritogenesis during cell exposure to extremely low frequency electromagnetic fields (ELF-EMFs) of different intensities and durations using pheochromocytoma-derived cell line (PC12 cells) as neuronal model. Methods. Proliferative rates and neuritogenesis were tested by colorimetric assay and morphological analysis, respectively; reactive oxygen species (ROS) levels and intracellular Ca²⁺ variations monitored using single cell videomicroscopy. Results. The long-lasting ELF-EMF exposure (0.1-1.0 mT) did not appear to significantly affect the biological response (proliferation and neuritogenesis). However, during the acute ELF-EMF exposure (30 min), in undifferentiated PC12 cells, there were increased ROS levels and decreased catalase activity, that, conversely, resulted increased after chronic exposure (7 days) at 1.0 mT. Acute exposure (0.1-1.0 mT) affected the spontaneous intracellular Ca²⁺ variations in undifferentiated cells, in which basal intracellular Ca²⁺ resulted increased after chronic exposure. In addition acute exposure affected cell response to a depolarizing agent, while basal membrane potential was not changed. Conclusion. Even if further studies remain necessary to identify the ROS/intracellular Ca²⁺cross-talking pathway activated by ELF-EMF exposure, we support the hypothesis that ROS and Ca²⁺ could be the cellular “primum movens” of the ELF-EMF induced effects on biological systems.

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Calmodulin‐dependent cyclic nucleotide phosphodiesterase activity is altered by 20 μT magnetostatic fields

Cited by 64 publications

References 12 publications

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Effect of alternating the magnetic feld on phosphate metabolism in the nervous system of Helix pomatia

Effects of Acute and Chronic Low Frequency Electromagnetic Field Exposure on PC12 Cells during Neuronal Differentiation

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