Callosal tracts and patterns of hemispheric dominance: A combined fMRI and DTI study

Häberling, Isabelle; Badzakova-Trajkov, Gjurgjica; Corballis, Michael C.

doi:10.1016/j.neuroimage.2010.09.072

Cited by 60 publications

(55 citation statements)

References 56 publications

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“…These results extended previous research on the neurobiological basis of temperaments to the anatomical fiber connectivity within the subcortical-cortical neural networks. Given that functional connectivity relies on structural connectivity (Boorman et al, 2007;Haberling et al, 2011), these temperament-related neuroanatomical circuits also provided anatomical support for previous findings of functional networks for temperaments (Gusnard et al, 2003;Jung et al, 2010;Krebs et al, 2009).…”

Section: Discussionsupporting

confidence: 70%

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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Section: Discussionsupporting

confidence: 70%

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

et al. 2014

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“…Studies combining DTI and behavioral measures have demonstrated a relationship between callosal microstructure and task performance under a range of cognitive and perceptual conditions (16)(17)(18). Indeed, individual differences in callosal organization might profoundly affect the information integration between the hemispheres (2,19).…”

Section: Neuroimaging and Network Theorymentioning

confidence: 99%

Dynamic network structure of interhemispheric coordination

Doron

Bassett

Gazzaniga

2012

Proc. Natl. Acad. Sci. U.S.A.

136

146

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Fifty years ago Gazzaniga and coworkers published a seminal article that discussed the separate roles of the cerebral hemispheres in humans. Today, the study of interhemispheric communication is facilitated by a battery of novel data analysis techniques drawn from across disciplinary boundaries, including dynamic systems theory and network theory. These techniques enable the characterization of dynamic changes in the brain's functional connectivity, thereby providing an unprecedented means of decoding interhemispheric communication. Here, we illustrate the use of these techniques to examine interhemispheric coordination in healthy human participants performing a split visual field experiment in which they process lexical stimuli. We find that interhemispheric coordination is greater when lexical information is introduced to the right hemisphere and must subsequently be transferred to the left hemisphere for language processing than when it is directly introduced to the language-dominant (left) hemisphere. Further, we find that putative functional modules defined by coherent interhemispheric coordination come online in a transient manner, highlighting the underlying dynamic nature of brain communication. Our work illustrates that recently developed dynamic, network-based analysis techniques can provide novel and previously unapproachable insights into the role of interhemispheric coordination in cognition.T he field of split-brain research began several decades ago with the use of a drastic surgical solution for intractable epilepsy (1-3): the severing of the corpus callosum. This procedure significantly decreased the connectivity between the hemispheres, thereby irrevocably altering interhemispheric communication. Although a few interhemispheric pathways remained through subcortical structures and the anterior commissure, examination of callosal function using split visual field experiments clearly demonstrated its role in interhemispheric communication (2). The callosal projection plays a particularly crucial role in a variety of sensory-motor integrative functions of the two hemispheres (4), shows changes with age, and demonstrates the potential for dynamic changes with training (5). In fact, experiments in patients with severance of the callosum revealed that it subserves a large range of behaviors and cognitive functions that underlie the varied workings of the mind.Interhemispheric communication has been studied using two basic approaches. The first uses behavioral experiments to examine cognitive phenotypes, and the second uses neuroscientific experiments to examine brain phenotypes. Split-brain research initially focused on the former: Patients demonstrated striking behavioral phenotypes that provided clues regarding the underlying mechanics of brain communication. For example, although most perceptual processing appears to be isolated in each hemisphere following surgery, some attentional and emotional mechanisms initiated in one hemisphere can still be communicated to the other, cortically disconnected,...

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“…Studies have only been conducted in healthy participants and they reported anatomo-functional relationships between the degree of leftward lateralization and CC features, but the results were still contradictory (Westerhausen et al, 2006;Josse et al, 2008;Haberling et al, 2011;Kompus et al, 2011). Westerhausen et al (2006) showed that mean diffusivity (MD, measured by diffusion tensor imaging, DTI) was lower in the CC (meaning thicker myelin sheaths) in participants who were strongly left-lateralized for language, compared with moderately leftlateralized, bilateral or right-lateralized participants, but the groups did not differ with respect to the area of the CC.…”

Section: Introductionmentioning

confidence: 99%

Left-hemisphere lateralization for language and interhemispheric fiber tracking in patients with schizophrenia

Leroux

Delcroix

Dollfus

2015

Schizophrenia Research

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Callosal tracts and patterns of hemispheric dominance: A combined fMRI and DTI study

Cited by 60 publications

References 56 publications

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Dynamic network structure of interhemispheric coordination

Left-hemisphere lateralization for language and interhemispheric fiber tracking in patients with schizophrenia

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