Callosal size in children with learning disabilities

Njiokiktjien, C; Sonneville, Leo de; Vaal, Juliette

doi:10.1016/0166-4328(94)90133-3

Cited by 62 publications

(32 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the lack of visually detectable abnormalities in corpus callosum, callosal size was reduced. Small corpus callosum, often corresponding to learning impairment, has been described in children with learning disabilities after perinatal adverse events [Njiokiktjien et al, 1994], and in fetal alcohol syndrome [Autti-Rämo et al, 2002]. In patients with SDS pons was also significantly smaller.…”

Section: Discussionmentioning

confidence: 94%

Shwachman–Diamond syndrome is associated with structural brain alterations on MRI

Toiviainen-Salo

Mäkitie

Mannerkoski

et al. 2008

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Shwachman-Diamond syndrome (SDS) is an autosomal recessive condition that results from mutations in the SBDS gene, at chromosome 7q11. Main features include exocrine pancreatic failure, neutropenia and skeletal dysplasia. This study investigated brain structures by magnetic resonance imaging (MRI) in patients with SDS. MRI of the brain was performed in nine patients (7 males, age range 7-37 years) with SDS and mutations in the SBDS gene and in 18 age- and gender-matched controls. MRI images were assessed visually, and volumetric analyses of the brain matter and structural midsagittal measurements were performed. Eight out of nine SBDS mutation-verified patients reported learning difficulties. Patients with SDS had smaller occipitofrontal head circumferences than the controls (Z-score -1.3 vs. +0.3, P = 0.021), and decreased global brain volume (1.74 L vs. 1.94 L, P = 0.019); both gray matter (P = 0.042) and white matter (P = 0.007) volumes were reduced. Patients with SDS had no macroscopic brain malformations, but they had significantly smaller age- and head size-adjusted areas of posterior fossa (P = 0.006), vermis (P = 0.002), corpus callosum (P = 0.020), and pons (P = 0.002), and significantly larger cerebrum-vermis ratio (P < 0.0001) than the healthy controls. SDS patients had structurally smaller posterior fossa and cerebellar vermis, corpus callosum, and brainstem than the healthy controls. The MRI findings may be related to the neuropsychological features described in SDS.

show abstract

Section: Discussionmentioning

confidence: 94%

Shwachman–Diamond syndrome is associated with structural brain alterations on MRI

Toiviainen-Salo

Mäkitie

Mannerkoski

et al. 2008

American J of Med Genetics Pt A

View full text Add to dashboard Cite

show abstract

“…Corpus callosum functioning has been linked to attention (Banich, 1998;Hynd et al, 1991;Roeltgen and Roeltgen, 1989), learning disabilities (Davidson et al, 1990;Njiokiktjien et al, 1994), and behavioral functioning (O'Brien, 1994). These areas of functioning are compromised in many children with heavy prenatal alcohol exposure.…”

Section: Discussionmentioning

confidence: 99%

Interhemispheric Transfer in Children with Heavy Prenatal Alcohol Exposure

Roebuck

Mattson

Riley

2002

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…Parents and teachers also completed Rutter A and B questionaries with Connor’s Hyperactivity Scale. A Child and Adolescent Psychiatric Assessment (CAPA) interview was conducted with the parent and child 14. Visual function studies of acuity, stereopsis, and contrast sensitivity were done.…”

Section: Methodsmentioning

confidence: 99%

Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence

Cooke¹,

Abernethy²,

Rutherford³

1999

Archives of Disease in Childhood - Fetal and Neonatal Edition

137

View full text Add to dashboard Cite

Aim-To determine whether neurological deficits are associated with structural anomalies of the brain in very low birthweight (VLBW) infants with subsequent learning disorders but without cerebral palsy, or whether other factors, such as poor early growth, are responsible. Methods-Eighty seven VLBW infants and eight term controls who had been examined at school between the ages of 12 and 13 years, had cranial magnetic resonance imaging (MRI) scans at 15-17 years of age. Results-Thirty seven (42.5%) of the VLBW children had abnormalities reported on their scans (two porencephaly, 28 periventricular leucomalacia, 24 ventricular dilatation, and 15 thinning of the corpus callosum). No significant diVerences in intelligence quotient, motor clumsiness, or frequency of attention deficit / hyperactivity disorder were observed between those children with MRI lesions and those with normal scans. Quantitative measurements showed the VLBW infants had smaller brains, and a relatively smaller corpus callosum compared with controls. No association between brain measurements and school performance was observed among the VLBW infants. Conclusions-The diYculties experienced by VLBW children at school are unlikely to be the result of perinatal brain injury, but they might to be attributable to the eVects of poor postnatal growth. (Arch Dis Child Fetal Neonatal Ed 1999;81:F116-F121)

show abstract

Callosal size in children with learning disabilities

Cited by 62 publications

References 23 publications

Shwachman–Diamond syndrome is associated with structural brain alterations on MRI

Shwachman–Diamond syndrome is associated with structural brain alterations on MRI

Interhemispheric Transfer in Children with Heavy Prenatal Alcohol Exposure

Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence

Contact Info

Product

Resources

About