Callosal role in generation of epileptiform discharges: quantitative analysis of EEGs recorded in patients undergoing corpus callosotomy

MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy

“…EEG research has shown that the corpus callosum facilitates bilateral hemisphere seizure susceptibility and/or interhemispheric transmission of epileptiform discharges [33]. Although the hippocampus does not directly project to the corpus callosum, the corpus callosum is important in the spread of epileptiform discharges to contralateral regions.…”

Post-section recruitment of epileptiform discharges in electrocorticography during callosotomy in 48 patients with Lennox–Gastaut syndrome

“…Bisynchronous ED in these patients would be decreased or even eliminated after callosotomy. Matsuo et al 16 reported that callosotomy unevenly reduced postoperative ED in both hemispheres, where this suggests a facilitating role played by callosal neurons that enables hemispheres with asymmetrical epileptogenic susceptibility to develop bisynchronous and bisymmetrical ED. This might explain why ED became independent on one side after callosotomy in some of our patients (Groups 1 and 2).…”

Predictive value of MEG using gradient magnetic field topography (GMFT) for seizure outcome following anterior corpus callosotomy (ACC) in patients with drop attacks

“…c o m / l o c a t e / c l i n p h synchrony and secondary generalized corticoreticular epileptic discharges. A reduction in the total number of EEG spikes is achieved after callosotomy (Matsuo et al, 2003). Callosal compound action potentials (CCAPs) recorded from the CC revealed hemispheric asymmetry of callosal neuronal participation in secondary bilateral synchrony (Ono et al, 2009).…”