Callosal involvement in a lateralized stroop task in alcoholic and healthy subjects.

Schulte, Tilman; Müller‐Oehring, Eva M.; Salo, Ruth; Pfefferbaum, Adolf; Sullivan, Edith V.

doi:10.1037/0894-4105.20.6.727

Cited by 25 publications

(20 citation statements)

References 75 publications

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“…Such neuropsychological deficits have classically been associated with impaired function of the frontal lobes, but more recently, also with alterations within the corticocerebellar circuit (Schmahmann and Pandya, 1997;Sullivan, 2003). Previous investigations on alcoholism have provided evidence of an association between white matter structure in the corpus callosum and certain components of executive functions, eg attention skills and inhibitory control (Schulte et al, 2006). In our own recent study, decreased white matter volume in the midbrain of alcoholdependent subjects was related to impaired performance in two executive tasks: the Trail-Making Test part-B (TMT-B) and the WAIS letter-number sequencing test (LNS; Chanraud et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Chanraud

Reynaud

Wessa

et al. 2008

Neuropsychopharmacol

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Components of the corticocerebellar circuit and the midbrain individually play a central role in addictive processes and have been associated with altered volumes and impairment of cognitive flexibility in alcohol-dependent subjects. The microstructure of white matter bundles composing the corticocerebellar network and passing through the midbrain was studied using diffusion tensor imaging in a group of detoxified alcohol-dependent men (n ¼ 20) and a group of healthy men (n ¼ 24). The relationship between properties of these white matter bundles and cognitive flexibility performance was investigated in alcohol-dependent subjects. Bundles connecting two regions of interest were analyzed using a fiber-tracking quantitative approach, which provided estimates of the fractional anisotropy and the apparent diffusion coefficient, as well as the number of tracked fibers normalized by the volume of regions of interest. Within the bundles running between the midbrain and pons, a mean of 18% fewer fibers per unit volume were tracked in alcohol-dependent men than in healthy controls. In addition, the normalized number of these fibers correlated with the performance in the Trail-Making Test part-B. Even though the alcohol-dependent subjects were detoxified and apparently neurologically intact, their earlier excessive use of alcohol seems to be associated with altered neural microstructure of mesencephalic white matter bundles, which may contribute to their cognitive flexibility impairment.

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Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Chanraud

Reynaud

Wessa

et al. 2008

Neuropsychopharmacol

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“…A number of different behavioral Chanraud et al (2013). paradigms have been devised to elicit response disinhibition, such as the GO/NOGO task (Colrain et al, 2011;Kamarajan et al, 2005), Stop-Signal task (Li, Luo, Yan, Bergquist, & Sinha, 2009), Balloon-Analogue Risk Task (Fein & Chang, 2008), and the Stroop color-word task (Schulte, Müller-Oehring, Pfefferbaum, & Sullivan, 2006), all based on the concept of inhibiting a natural or learned compelling response and amendable to testing with fMRI. A common finding in task-activated paradigms tapping response inhibition has been weaker connectivity in frontostriatal networks in alcoholics compared with controls (Courtney, Ghahremani, & Ray, 2013).…”

Section: Frontostriatal Circuitrymentioning

confidence: 99%

“…The Stroop Match-to-Sample Task (Schulte et al, 2006) is such a task and was designed to engage cognitive processes involving attentional control and conflict resolution when automatic processing of task-irrelevant word content interferes. One set of findings from this paradigm found that healthy young adults (aged 19-30 years) activated an anterior network for Stroop-match, and a posterior network was activated for Stroop-nonmatch.…”

Section: Frontostriatal Circuitrymentioning

confidence: 99%

Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism

Sullivan

Pfefferbaum

2014

Neurobiology of Alcohol Dependence

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“…We presented the two stimuli sequentially in order to address attentional allocation with the color patch acting as a cue (Posner and Peterson 1990). The paradoxical finding that greater Stroop effects occur when the cue color correctly predicts the color of the Stroop word (match) than when the color cue misdirects attention in non-match trials (Schulte et al 2005) is a stable phenomenon that we observed in different neuropsychiatric conditions and with different subjects (Schulte et al 2006(Schulte et al , 2007. It is further consistent with another study by Chen (2003), who found that the Stroop interference was greater when the cue was valid than when it was invalid.…”

mentioning

confidence: 91%

“…Using the Match-to-Sample Stroop task, we observed that individuals with HIV performed at a comparable level to controls in conflict processing and attentional allocation, whereas alcoholics showed prolonged reaction times (RT) on this task, and those with HIV+alcoholism were even slower. A greater Stroop effect in alcoholics was related to a smaller size of the corpus callosum suggesting involvement of callosal interhemispheric pathways in word-color Stroop processes that becomes apparent when callosal integrity is compromised (Schulte et al 2006). Diffusion tensor imaging (DTI) derived measures of microstructure in alcoholism (Pfefferbaum et al , 2006a and HIV (Pfefferbaum et al 2006b may reveal even more robust effects than MRI-derived measures of callosal size in identifying disruptions in regional callosal systems that contribute to lateralized components of attentional allocation and conflict processing (Pfefferbaum et al 1997;.…”

mentioning

confidence: 99%

Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity

Schulte

Müller‐Oehring

Javitz

et al. 2007

Brain Imaging and Behavior

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Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution assessed by a novel Stroop Match-to-Sample task. We tested 16 ALC, 19 HIV, 20 subjects with combined disorder and 17 controls. In ALC, low fractional anisotropy and high mean diffusivity throughout the CC correlated with poor Stroop-match performance, i.e., when the cue-color matched the color of the Stroop stimulus. By contrast, in the two HIV groups DTI relations were restricted to the genu and poor Stroop-nonmatch performance, i.e., when the cue-color was in conflict with the Stroop stimulus color. These results suggest that disruption of callosal integrity in HIV-infection and alcoholism differentially affects regionally-selective interhemispheric-dependent attentional processing. We speculate that callosal degradation in these diseases curtails the opportunity for collaboration between the two hemispheres that contributes to normal performance in HIV or alcoholic patients with higher callosal integrity. KeywordsDiffusion tensor imaging; HIV infection; Alcoholism; Stroop; Selective attention; Corpus callosum A frequent comorbidity in individuals infected with human immunodeficiency virus (HIV) is alcohol use disorder (Justice et al. 2006;Lefevre et al. 1995;Meyerhoff 2001;Molina et al. 2006;Winsauer et al. 2002). Each disorder exerts adversive effects on cognitive function and brain structure, some different and some overlapping. Although both disorders affect attention, each can selectively disrupt different component processes of this NIH Public Access Author ManuscriptBrain Imaging Behav. Author manuscript; available in PMC 2009 April 8. Published in final edited form as:Brain Imaging Behav. 2008 ; 2(1): 27-38. doi:10.1007/s11682-007-9014-z. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript complex cognitive process. Chronic alcoholism adversely disrupts executive control mechanisms relying on prefrontal and parietal attentional brain systems (Nixon et al. 1988;Sullivan et al. 2000;Tapert et al. 2001). Lack of executive function control over attentional systems has also been reported in patients infected with human immunodeficiency virus (HIV) (Chao et al. 2004;Hinkin et al. 1999;McArthur 2004;Sahakian et al. 1995).The Stroop Color Word Test (Stroop 1935) is a widely used paradigm to study selective attentional processes that require conflict resolution and response inhibition between competing stimulus attributes (Bush et al. 2003;Carter et al. 1999;Fan et al. 2003;MacDonald et al. 2000;Salo et al. 2001). The Stroop phenomenon describes slower responses when subjects are asked to name the ink color of a word printed in a color incongruent with the word's meaning (e.g., the word "red" written in blue ink) relative to when the word's meaning and ink color are the same (e.g., the word "red" written in red ink). When the relevant color-attribute and the irrelevant word-...

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Callosal involvement in a lateralized stroop task in alcoholic and healthy subjects.

Cited by 25 publications

References 75 publications

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism

Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity

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