Callicarpa japonica Thunb. reduces inflammatory responses: A mouse model of lipopolysaccharide-induced acute lung injury

Shin, Na‐Rae; Shin, In‐Sik; Song, Hyuk‐Hwan; Hong, Ju-Mi; Kwon, Ok‐Kyoung; Jeon, Chan‐Mi; Kim, Jung-Hee; Lee, Sang‐Woo; Lee, Dong Kun; Jin, Hang; Li, Wan Yi; Oh, Sei‐Ryang; Hahn, Kyu‑Woung; Ahn, Ki Hoon

doi:10.1016/j.intimp.2015.01.025

Cited by 24 publications

(21 citation statements)

References 37 publications

(6 reference statements)

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“…Among all these downstream targets, TNF-α may be regarded as the most fundamental one for its inducing capacity on activation and accumulation of leukocytes (Li et al, 2018), as well as further initiation of inflammatory cascade by stimulating IL-6 and IL-1β generation (He et al, 2016). The resulting IL-6 has proven to be crucial in mediating the release of neutrophils and vascular active substances, which may cause serious tissue impairment (Shin et al, 2015;Lee et al, 2010). Similarly, IL-1β also plays an essential role in the occurrence of visceral organs injuries.…”

Section: Molecular Mechanism For Inflammationmentioning

confidence: 99%

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Wang¹,

Li²,

Wei³

et al. 2018

JFB

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Inflammation is a non-specific kind of biological immune response of body tissues to any type of external or internal injuries, such as pathogens, irritants and immune stress reactions. There are two types of inflammation, namely acute and chronic. Acute inflammation starts and develops rapidly, and is aroused by various factors, including injuries, infection, toxins or immune reactions. Chronic inflammation usually lasts for an extended long period of time and results from elimination failure of acute inflammation, autoimmune disorders, various pathogens and pathogenic environments. Except for the damage itself, there exists a direct and intimate connection between chronic inflammation and various clinic common diseases, such as neurodegeneration, as well as metabolic and cardiovascular ailments. Citrus peel is a by-product generated in citrus juice processing. Polymethoxyflavones (PMFs) exist abundantly and almost exclusively in citrus peels, and their biological activities have been broadly investigated in recent years. PMFs have proven to possess potential inhibitory bioactivities towards a number of functional and immune diseases including inflammation. The two most abundant PMFs exhibiting prominent bioactivities in citrus peels are nobiletin and tangeretin, ubiquitously detected in various citrus species. In this review, the beneficial health effects and the underlying molecular mechanisms of ten main citrus PMFs were illustrated against numerous inflammatory diseases, including inflammatory bowel disease (IBD), neuroinflammation and organ inflammation, among others.

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Section: Molecular Mechanism For Inflammationmentioning

confidence: 99%

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Wang¹,

Li²,

Wei³

et al. 2018

JFB

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“…SP and DEX were orally administered from day 0 to day 5. DEX was used as a positive control [7]. The mice were treated with LPS (form Escherichia coli O111:B4; Sigma-Aldrich) 20 µg in 50 µL phosphate-buffered saline (PBS; Gibco, San Diego, CA, USA) by intranasal (i.n.)…”

Section: Lps-induced Ali Model and Differential Cell Count In Bronchomentioning

confidence: 99%

“…Lipopolysaccharide (LPS), from the outer membrane of gram-negative bacteria, enhances oxidative stress by generating of reactive oxygen species (ROS) and an inflammatory response in an experimental animal model of ALI [7][8][9][10]. LPS is recognized by toll-like receptor 4 (TLR4), which activates downstream signaling via nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways [11].…”

Section: Introductionmentioning

confidence: 99%

“…Emerging evidence indicates that Nrf2 activation plays a protective role against LPS-induced oxidative stress and inflammation in the LPS-induced ALI model [14,18]. Recently, many researchers have begun to investigate the effects of herbal-derived natural products with anti-oxidant or anti-inflammatory properties on ALI [7,19].…”

Section: Introductionmentioning

confidence: 99%

“…BALF collection was performed while using the method of Shin et al [7]. Briefly, ice-cold PBS (0.7 mL) was infused into the lungs twice and withdrawn each time using a tracheal cannula to obtain the BALF (a total volume of 1.4 mL).…”

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confidence: 99%

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Spiraea prunifolia var. simpliciflora Attenuates Oxidative Stress and Inflammatory Responses in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury and TNF-α-Stimulated NCI-H292 Cells

Lee

Shin

et al. 2020

Antioxidants

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Spiraea prunifolia var. simpliciflora (SP) is traditionally used as an herbal remedy to treat fever, malaria, and emesis. This study aimed to evaluate the anti-oxidative and anti-inflammatory properties of the methanol extract of SP leaves in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells and in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. SP decreased the number of inflammatory cells and the levels of TNF-α, interleukin (IL)-1β, and IL-6 in the bronchoalveolar lavage fluid, and inflammatory cell infiltration in the lung tissues of SP-treated mice. In addition, SP significantly suppressed the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in TNF-α-stimulated NCI-H292 cells. SP significantly suppressed the phosphorylation of the mitogen-activated protein kinases (MAPKs) and p65-nuclear factor-kappa B (NF-κB) in LPS-induced ALI mice and TNF-α-stimulated NCI-H292 cells. SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-α-stimulated NCI-H292 cells. Collectively, SP effectively inhibited airway inflammation and ROS-mediated oxidative stress, which was closely related to its ability to induce activation of Nrf2 and inhibit the phosphorylation of MAPKs and NF-κB. These findings suggest that SP has therapeutic potential for the treatment of ALI.

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Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-κB Pathway In Vivo and Vitro

et al. 2018

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Nobiletin (NOB), a citrus polymethoxy flavonoid, has been reported to exhibit anti-inflammatory, anti-cancer, and anti-insulin resistance activities. Although the anti-inflammatory activity of NOB already reported, its involvement in lung protection has not been reported. Thus, this study aimed to investigate the anti-inflammatory response of NOB in lipopolysaccharide (LPS)-stimulated A549 cells and LPS-induced acute lung injury (ALI) in mice. The animals were pre-treated with NOB (5, 10, and 20 mg/kg) or DEX (5 mg/kg) at 12 and 1 h before intranasal instillation of LPS. The severity of pulmonary injury was evaluated 6 h after LPS administration. Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-α, IL-6, and NO in BALF induced by LPS. Furthermore, NOB also significantly inhibited the expression of iNOS and the phosphorylation of NF-κBp65 and IκBα. In vitro, NOB inhibited NF-κB activation and TNF-α, IL-6 production in LPS-stimulated A549 cells. Taken together, these results indicated that NOB exhibited a protective effect on ALI, and the possible mechanism is involved in inhibiting NF-κB activation, subsequently inhibiting LPS-induced inflammatory response.

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Callicarpa japonica Thunb. reduces inflammatory responses: A mouse model of lipopolysaccharide-induced acute lung injury

Cited by 24 publications

References 37 publications

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Anti-inflammatory effects of polymethoxyflavones from citrus peels: a review

Spiraea prunifolia var. simpliciflora Attenuates Oxidative Stress and Inflammatory Responses in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury and TNF-α-Stimulated NCI-H292 Cells

Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-κB Pathway In Vivo and Vitro

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