Calliandra surinamensis lectin (CasuL) does not impair the functionality of mice splenocytes, promoting cell signaling and cytokine production

Procópio, Thamara Figueiredo; Patriota, Leydianne Leite de Siqueira; Barros, Bárbara Rafaela da Silva; Aguiar, Lethícia Maria de Souza; Lorena, Virgínia Maria Barros de; Paiva, Patrícia Maria Guedes; Melo, Cristiane Moutinho Lagos de; Napoleão, Thiago Henrique

doi:10.1016/j.biopha.2018.08.043

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…This potentially offers antiinflammatory properties via the lectin domain in legumes, and demonstrates immunomodulatory effects [234][235][236][237][238]. Additionally, these proteins demonstrate antifungal action and generation of cytokines in both in vitro and in vivo [239][240][241]. Pea lectin was specifically found to trigger apoptosis in some human colon cancer cells, while chickpea lectin was able to cause apoptosis of human breast cancer [242,243].…”

Section: Uses Of Antinutritional Factors In Research and Future Direc...mentioning

confidence: 99%

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

Shea,

Ogando do Granja,

Fletcher

et al. 2024

CIMB

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The global demand for sustainable and nutritious food sources has catalyzed interest in legumes, known for their rich repertoire of health-promoting compounds. This review delves into the diverse array of bioactive peptides, protein subunits, isoflavones, antinutritional factors, and saponins found in the primary legume protein sources—soybeans, peas, chickpeas, and mung beans. The current state of research on these compounds is critically evaluated, with an emphasis on the potential health benefits, ranging from antioxidant and anticancer properties to the management of chronic diseases such as diabetes and hypertension. The extensively studied soybean is highlighted and the relatively unexplored potential of other legumes is also included, pointing to a significant, underutilized resource for developing health-enhancing foods. The review advocates for future interdisciplinary research to further unravel the mechanisms of action of these bioactive compounds and to explore their synergistic effects. The ultimate goal is to leverage the full spectrum of benefits offered by legumes, not only to advance human health but also to contribute to the sustainability of food systems. By providing a comprehensive overview of the nutraceutical potential of legumes, this manuscript sets a foundation for future investigations aimed at optimizing the use of legumes in the global pursuit of health and nutritional security.

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Section: Uses Of Antinutritional Factors In Research and Future Direc...mentioning

confidence: 99%

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

Shea,

Ogando do Granja,

Fletcher

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…Besides its agricultural importance, also arouses clinical interest due activities such as antinociceptive , anti-inflammatory and antihemolytic activity [10][11][12], healing of cutaneous wounds [13], control of the metastatic potential of tumor cells through mechanisms induces anti-angiogenic activity and apoptosis [14][15][16], anti-inflammatory activity due to the ability to inhibit the neutrophil migration and to reduce IL1-β and TNF-α levels [17], immunomodulatory effect, NO production [18,19], induction of mitosis [20], cytokine production in vitro and in vivo [21] and antifungal action [22][23][24].…”

Section: Highlightsmentioning

confidence: 99%

“…In its antibacterial activity, it had bacteriostatic effect for Brazilian Archives of Biology and Technology. Vol.64: e21200631, 2021 www.scielo.br/babt Staphylococcus saprophyticus and S. aureus, the antibiofilm activity was more significant than inhibition of bacterial growth, especially for S. saprophyticus, which shows that CasuL has a potential that needs evaluation to be used to cover surfaces [21].…”

Section: Antibacterial Activity Of Plant Lectinsmentioning

confidence: 99%

Antibacterial Activity of Plant Lectins: a Review

Silva

Araújo

2021

Braz. arch. biol. technol.

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Lectins are proteins that form a heterogeneous group, capable of binding specifically and reversibly to carbohydrates. They occur in various types of organisms, having different functions, in plants they are present in almost all structures, however with greater proportion in seeds roots and rhizomes. This review aims to provide a more detailed understanding of the antibacterial action of lectins and their biotechnological potential against pathogenic bacteria in the last ten years. Several mechanisms of action are described for the antibacterial activity of these proteins among which the best known occurs due to the interaction between the binding site of the lectin and the carbohydrates exposed on the bacterial cell surface. In vivo studies demonstrate that lectins act on the cascade of cytokines and influencing the level of nitric oxide as ways to decrease bacterial infection. To date, lectins have performed a wide antibacterial activity, emphasizing that each lectin acts according to its carbohydrate specificity, in this way, it is possible to have a distinct performance according to the plant species that are extracted. Thus, being an alternative to the antibacterial resistance that occurs in response to antibiotics. Furthermore, more studies with this theme are necessary for clinical application.

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Biosynthesized silver nanoparticles prevent bacterial infection in chicken egg model and mitigate biofilm formation on medical catheters

Pradhan,

Sah,

Nayak

et al. 2024

J Biol Inorg Chem

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Calliandra surinamensis lectin (CasuL) does not impair the functionality of mice splenocytes, promoting cell signaling and cytokine production

Cited by 8 publications

References 42 publications

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

Antibacterial Activity of Plant Lectins: a Review

Biosynthesized silver nanoparticles prevent bacterial infection in chicken egg model and mitigate biofilm formation on medical catheters

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