Call the Plumber: Impaired Meningeal Lymphatic Drainage in Parkinson's Disease

Visanji, Naomi P.; Lang, Anthony E.

doi:10.1002/mds.28590

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Meningeal Immune System Response To Central Neural System Di...1

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2022

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“…In recent years, a vast body of studies has found that the MIS is related to the occurrence, progression, or prognosis of more CNS diseases to varying degrees. For example, the MIS is believed to play important roles in the pathogenesis of multiple sclerosis ( 26 , 88 – 90 ), Alzheimer’s disease ( 35 , 91 – 93 ), and Parkinson’s disease ( 78 , 94 , 95 ). Meanwhile, the regulation of the MIS about the immune surveillance and lymphatic vessel drainage to the brain tumor is also demonstrated ( 96 – 98 ).…”

Section: Meningeal Immune System Response To Central Neural System Di...mentioning

confidence: 99%

New insight into DAVF pathology—Clues from meningeal immunity

Peng

Song

et al. 2022

Front. Immunol.

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In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape. The latest concept of meningeal immune system is a tertiary structure, which is a comprehensive overview of the meningeal immune system from macro to micro. We comprehensively reviewed recent advances in meningeal immunity, particularly the new understanding of the dural sinus and meningeal lymphatics. Moreover, based on the clues from the meningeal immunity, new insights were proposed into the dural arteriovenous fistula (DAVF) pathology, aiming to provide novel ideas for DAVF understanding.

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