Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health

Atwoli, Lukoye; Baqui, Abdullah H; Benfield, Thomas; Bosurgi, Raffaella; Godlee, Fiona; Hancocks, Stephen; Horton, Richard; Laybourn‐Langton, Laurie; Monteiro, Carlos Augusto; Norman, Ian; Patrick, Kirsten; Praities, Nigel; Rikkert, Marcel G M Olde; Rubín, Eric J.; Sahni, Peush; Smith, Richard; Talley, Nick; Turale, Sue; Vázquez, Damián

doi:10.1056/nejme2113200

Cited by 137 publications

(63 citation statements)

References 8 publications

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“…The heat stress response (HSR) is a universal defense mechanism to reestablish homeostasis. In the era of global warming, the understanding of HSR is more necessary than ever before for both health [4] and economic reasons.…”

Section: Introductionmentioning

confidence: 99%

Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe

Péter

Gudmann

Kóta

et al. 2021

IJMS

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Homeostatic maintenance of the physicochemical properties of cellular membranes is essential for life. In yeast, trehalose accumulation and lipid remodeling enable rapid adaptation to perturbations, but their crosstalk was not investigated. Here we report about the first in-depth, mass spectrometry-based lipidomic analysis on heat-stressed Schizosaccharomyces pombe mutants which are unable to synthesize (tps1Δ) or degrade (ntp1Δ) trehalose. Our experiments provide data about the role of trehalose as a membrane protectant in heat stress. We show that under conditions of trehalose deficiency, heat stress induced a comprehensive, distinctively high-degree lipidome reshaping in which structural, signaling and storage lipids acted in concert. In the absence of trehalose, membrane lipid remodeling was more pronounced and increased with increasing stress dose. It could be characterized by decreasing unsaturation and increasing acyl chain length, and required de novo synthesis of stearic acid (18:0) and very long-chain fatty acids to serve membrane rigidification. In addition, we detected enhanced and sustained signaling lipid generation to ensure transient cell cycle arrest as well as more intense triglyceride synthesis to accommodate membrane lipid-derived oleic acid (18:1) and newly synthesized but unused fatty acids. We also demonstrate that these changes were able to partially substitute for the missing role of trehalose and conferred measurable stress tolerance to fission yeast cells.

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Section: Introductionmentioning

confidence: 99%

Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe

Péter

Gudmann

Kóta

et al. 2021

IJMS

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“…In a joint editorial, the New England Journal of Medicine [17] and 18 other medical journals called 'for urgent action to keep average global temperature increases below 1.5 C, halt the destruction of nature, and protect health'. We think we all need to join that call.…”

Section: Why Us?mentioning

confidence: 99%

Curing a Malignant Climate

2022

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“…11 12 Despite global efforts to secure commitments to limit global warming to 1.5°C, 13 there is growing recognition that climate change is already the greatest risk facing human health. [14][15][16] There is a need for greater consideration of the impact of climate change on injury risk, particularly drowning. Such impacts are likely to be many and wide-ranging, some obvious, such as drowning during more frequent flooding events, and some not, such as changes in drowning risk associated with longer-term shifts in seasonal patterns.…”

Section: Introductionmentioning

confidence: 99%

Drowning risk and climate change: a state-of-the-art review

et al. 2022

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Drowning and climate change are both significant global health threats, yet little research links climate change to drowning risk. Research into the epidemiology, risk factors and preventive strategies for unintentional drowning in high-income and in low-income and middle-income countries has expanded understanding, but understanding of disaster and extreme weather-related drowning needs research focus. As nation states and researchers call for action on climate change, its impact on drowning has been largely ignored. This state-of-the-art review considers existing literature on climate change as a contributor to changes in drowning risks globally. Using selected climate change-related risks identified by the World Meteorological Organization and key risks to the Sustainable Development Goals as a framework, we consider the drowning risks associated with heat waves, hydrometeorological hazards, drought and water scarcity, damaged infrastructure, marine ecosystem collapse, displacement, and rising poverty and inequality. Although the degree of atmospheric warming remains uncertain, the impact of climate change on drowning risk is already taking place and can no longer be ignored. Greater evidence characterising the links between drowning and climate change across both high-income and low-income and middle-income contexts is required, and the implementation and evaluation of drowning interventions must reflect climate change risks at a local level, accounting for both geographical variation and the consequences of inequality. Furthermore, collaboration between the injury prevention, disaster risk reduction and climate change mitigation sectors is crucial to both prevent climate change from stalling progress on preventing drowning and further advocate for climate change mitigation as a drowning risk reduction mechanism.

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Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health

Cited by 137 publications

References 8 publications

Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe

Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe

Curing a Malignant Climate

Drowning risk and climate change: a state-of-the-art review

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