Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic

Khalil, Asma; Samara, Athina; O’Brien, Pat; Ladhani, Shamez

doi:10.1038/s41467-022-32638-w

Cited by 15 publications

(16 citation statements)

References 6 publications

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“…148 Therefore, more attention is needed cause individuals such as children and pregnant women are more susceptible with increasing cases. 145,147,[149][150][151][152][153][154][155][156][157] Notably, a very recent report proved that human-to-dog transmission of monkeypox virus. 158 Nextgeneration sequencing was used to compare the DNA sequences of the monkeypox virus from the dog and the patient.…”

Section: Epidemiology Of Monkeypoxmentioning

confidence: 99%

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Huang

Wang

2022

Sig Transduct Target Ther

145

120

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Monkeypox is a zoonotic disease that was once endemic in west and central Africa caused by monkeypox virus. However, cases recently have been confirmed in many nonendemic countries outside of Africa. WHO declared the ongoing monkeypox outbreak to be a public health emergency of international concern on July 23, 2022, in the context of the COVID-19 pandemic. The rapidly increasing number of confirmed cases could pose a threat to the international community. Here, we review the epidemiology of monkeypox, monkeypox virus reservoirs, novel transmission patterns, mutations and mechanisms of viral infection, clinical characteristics, laboratory diagnosis and treatment measures. In addition, strategies for the prevention, such as vaccination of smallpox vaccine, is also included. Current epidemiological data indicate that high frequency of human-to-human transmission could lead to further outbreaks, especially among men who have sex with men. The development of antiviral drugs and vaccines against monkeypox virus is urgently needed, despite some therapeutic effects of currently used drugs in the clinic. We provide useful information to improve the understanding of monkeypox virus and give guidance for the government and relative agency to prevent and control the further spread of monkeypox virus.

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Section: Epidemiology Of Monkeypoxmentioning

confidence: 99%

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Huang

Wang

2022

Sig Transduct Target Ther

145

120

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“…However, cesarean delivery is recommended if the mother presents with genital or anorectal lesions and/or PCR tests are not available. General anesthesia and neuraxial anesthesia considerations are necessary to be considered if oropharyngeal or cutaneous lesions near the insertion site, respectively, do exist [ 36 , 44 , 45 , 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…Breastfeeding should be delayed during the isolation period, and breastmilk should be pumped and discarded. In high-risk neonates with positive PCR, breastfeeding may be considered provided there are no lesions on the mother’s breast [ 36 , 39 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on existing studies of the safety/effectiveness of immunoglobulins administered, in pregnancy an antibody cocktail purified from the blood of individuals previously immunized with the smallpox vaccine can be proposed. Lastly, the limited data available on safety or efficacy of the smallpox vaccine, MVA-BN hinder evidence-based care for this high-risk group [ 45 , 46 , 47 ] (see details in next section).…”

Section: Resultsmentioning

confidence: 99%

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Monkeypox Infection 2022: An Updated Narrative Review Focusing on the Neonatal and Pediatric Population

Gaeta

Franci

et al. 2022

Children

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Monkeypox disease has been endemic in sub-Saharan Africa for decades, attracting remarkable attention only i23n 2022 through the occurrence of a multi-country outbreak. The latter has raised serious public health concerns and is considered a public health emergency by the World Health Organization. Although the disease is usually self-limiting, it can cause severe illness in individuals with compromised immune systems, in children, and/or the pregnant woman–fetus dyad. Patients generally present with fever, lymphadenopathy, and a vesicular rash suggestive of mild smallpox. Serious eye, lung and brain complications, and sepsis can occur. However, cases with subtler clinical presentations have been reported in the recent outbreak. A supportive care system is usually sufficient; otherwise, treatment options are needed in patients who are immunocompromised or with comorbidities. A replication-deficient modified and a live infectious vaccinia virus vaccine can be used both before and after exposure. Due to the persistent spread of monkeypox, it is necessary to focus on the pediatric population, pregnant women, and newborns, who represent fragile contagion groups. Here we assess and summarize the available up-to-date information, focusing on available therapeutic options, with insights into social and school management, breastfeeding, and prevention that will be useful for the scientific community and in particular neonatal and pediatric health professionals.

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“…Finally, WAPM encourages active participation in the collection of robust data in this setting to improve the knowledge and ultimate care of women and children. [31,32] Funding: This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.…”

Section: Neonatal Care Rooming In and Breastfeedingmentioning

confidence: 99%

Monkeypox in pregnancy: clinical recommendation by the World Association of Perinatal Medicine-WAPM and the Perinatal Medicine Foundation-PMF

Villalaín¹,

Şen²,

Allegeart³

et al. 2022

Perinat J

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The World Health Organization in May 2022 declared the monkeypox virus (MPXV) a health emergency. Since then, over 45,355 cases have been reported, mostly from countries where the disease is not endemic. At the moment, most confirmed cases with travel history are reported to countries in Europe and North America, rather than West or Central Africa where the monkeypox virus is endemic. Its transmission depends on large respiratory droplets and skin-to-skin or skin-to-lesion close physical contact, including oral, anal, and vaginal intercourse therefore, women are also at risk of acquiring it. Given few data available, women’s and clinicians’ concerns about the uncertainty of the clinical course and management are more than understandable, especially so after the SARS-CoV-2 pandemic. Lessons must be learnt from our prior mistakes and pregnant individuals should be included in international registries as well as any studies evaluating new treatments or vaccines. The following recommendation aims to provide the latest evidence about the effect of MPXV in pregnancy as well as recommendations for clinical management.

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Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic

Cited by 15 publications

References 6 publications

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Monkeypox Infection 2022: An Updated Narrative Review Focusing on the Neonatal and Pediatric Population

Monkeypox in pregnancy: clinical recommendation by the World Association of Perinatal Medicine-WAPM and the Perinatal Medicine Foundation-PMF

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