Calixarene-based porous coordination compound as microreactors: Enrichment-enhanced electrochemiluminescence of iridium(III) complex for bioanalysis

Yang, Guomin; Zhang, Jiamao; Hu, Shanshan; Wang, Shentang; Yuan, Ruo; Chen, Shihong

doi:10.1016/j.cej.2023.142812

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…First, SWU-1 was prepared by referring to our previous work . The detailed synthesis progress of SWU-1 is as follows.…”

Section: Methodsmentioning

confidence: 99%

“…The structure of SWU-1 is depicted in Figure S1. The corresponding SQUEEZE RESULT, thermogravimetric (TG) analysis, and crystallographic characterization of SWU-1 have been elaborated on in our previous work …”

Section: Methodsmentioning

confidence: 99%

“…First, SWU-1 was prepared by referring to our previous work. 24 The detailed synthesis progress of SWU-1 is as follows. The mixed solution of N-methylpyrrolidone/methanol (NMP/CH 3 OH) (5.0 mL, v/v, 1/4) was used to dissolve p-tert-butylsulfonylcalix [4]arene (H 4 TC 4 A-SO 2 ) (85.0 mg) and cobalt chloride hydrate (CoCl 2 • 6H 2 O) (95.0 mg).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…The corresponding SQUEEZE RESULT, thermogravimetric (TG) analysis, and crystallographic characterization of SWU-1 have been elaborated on in our previous work. 24 Then, a nanoprecipitation method was employed to prepare TCPP@SWU-1 NCs, and the details were as follows: 0.2 mg of SWU-1 and 2.0 mg of TCPP were added in tetrahydrofuran (THF), respectively. After ultrasonic treatment for 4 h, two solutions (1.0 mg/mL) were obtained.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…In our previous work, we prepared a cage-like porous complex with large porosity and ordered pore structure (called SWU-1) and demonstrated that SWU-1 can serve as a microreactor to load Ir(ppy) 3 and enrich the coreactant, thus enhancing its ECL emission. 24 Obviously, SWU-1 showed great potential in restricting porphyrin molecular aggregation to improve ECL emission and even mediating double emission. In this study, the cage-like porous complex SWU-1 was creatively developed as a microreactor to weaken the ACQ effect of meso-tetra(4-carboxyphenyl)porphine (TCPP) while modulating its dual ECL emission.…”

Section: ■ Introductionmentioning

confidence: 99%

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Porous Complex-Mediated Dual Emission of Porphyrins for the Electrochemiluminescence Bioassay

Wen,

Yang,

Yang

et al. 2024

Anal. Chem.

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Although porphyrins make up a promising class of electrochemiluminescence (ECL) luminophors, their aggregation-caused quenching (ACQ) characteristics lead to inferior ECL efficiency (ΦECL). Furthermore, current application of porphyrins is limited to cathodic emission. This work creatively exploited a cage-like porous complex (referred to as SWU-1) as the microreactor to recede the ACQ effect while modulating dual ECL emission of meso-tetra(4-carboxyphenyl)porphine (TCPP), which self-assembled with SWU-1 to form TCPP@SWU-1 nanocapsules (TCPP@SWU-1 NCs). As the microreactor, SWU-1 not only effectively constrained TCPP aggregation to improve electron–hole recombination efficiency but also improved stability of anion and cation radicals, thus significantly enhancing the dual emission of TCPP. Compared with TCPP aggregates, the resulting TCPP@SWU-1 NCs exhibited significantly enhanced anodic and cathodic emission, and their ΦECL was increased by 8.7-fold and 3.9-fold, respectively. Furthermore, black hole quencher-2 (BHQ2) can simultaneously quench anodic and cathodic signals. TCPP@SWU-1 NCs coupling BHQ2 conveniently achieved an ECL ratio detection of miRNA-126, and the limit of detection (S/N = 3) was 4.1 aM. This work pioneered the development of the cage-like porous complex SWU-1 as the microreactor to alleviate defects of the ACQ effect and mediate dual emission of TCPP. The coupling of dual-emitting TCPP@SWU-1 NCs and dual-function moderator BHQ2 created a novel single-luminophor-based ratio system for bioanalysis and provided a promising ECL analysis approach for miRNA-126.

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“…First, SWU-1 was prepared by referring to our previous work . The detailed synthesis progress of SWU-1 is as follows.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Porous Complex-Mediated Dual Emission of Porphyrins for the Electrochemiluminescence Bioassay

Wen,

Yang,

Yang

et al. 2024

Anal. Chem.

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Recent Advances in Electrochemiluminescence Biosensors for MicroRNA Detection

Meng,

Pang,

Yang

et al. 2023

Small

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Electrochemiluminescence (ECL) as an analytical technology with a perfect combination of electrochemistry and spectroscopy has received considerable attention in bioanalysis due to its high sensitivity and broad dynamic range. Given the selectivity of bio‐recognition elements and the high sensitivity of the ECL analysis technique, ECL biosensors are powerful platforms for the sensitive detection of biomarkers, achieving the accurate prognosis and diagnosis of diseases. MicroRNAs (miRNAs) are crucial biomarkers involved in a variety of physiological and pathological processes, whose aberrant expression is often related to serious diseases, especially cancers. ECL biosensors can fulfill the highly sensitive and selective requirements for accurate miRNA detection, prompting this review. The ECL mechanisms are initially introduced and subsequently categorize the ECL biosensors for miRNA detection in terms of the quenching agents. Furthermore, the work highlights the signal amplification strategies for enhancing ECL signal to improve the sensitivity of miRNA detection and finally concludes by looking at the challenges and opportunities in ECL biosensors for miRNA detection.

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Near-infrared electrochemiluminescence of carbon nitride quantum dots for ultrasensitive microRNA assay

Liu,

Xu,

Zhu

et al. 2023

Chemical Engineering Journal

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Calixarene-based porous coordination compound as microreactors: Enrichment-enhanced electrochemiluminescence of iridium(III) complex for bioanalysis

Cited by 12 publications

References 24 publications

Porous Complex-Mediated Dual Emission of Porphyrins for the Electrochemiluminescence Bioassay

Porous Complex-Mediated Dual Emission of Porphyrins for the Electrochemiluminescence Bioassay

Recent Advances in Electrochemiluminescence Biosensors for MicroRNA Detection

Near-infrared electrochemiluminescence of carbon nitride quantum dots for ultrasensitive microRNA assay

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