Calix[6]arene Derivatives with Differently Modified Bridges

Shalev, Ori; Biali, Silvio E.

doi:10.1002/ejoc.201901898

Cited by 1 publication

(2 citation statements)

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“…Very recently, a calix[6]arene derivative bearing two distal carbonyl and four bridges monobrominated was synthesized and structurally characterized as the chiral all‐trans isomer [60] . It was observed that solvolysis of macrocycle 14 a in methanol resulted in replacement of the bromines by methoxy groups to afford the all‐trans product 14 b .…”

Section: Upper Rim Direct C‐h Functionalizationmentioning

confidence: 99%

“…[59] Very recently, a calix [6]arene derivative bearing two distal carbonyl and four bridges monobrominated was synthesized and structurally characterized as the chiral all-trans isomer. [60] It was observed that solvolysis of macrocycle 14 a in methanol resulted in replacement of the bromines by methoxy groups to afford the all-trans product 14 b. In addition, tetrabromodioxocalix [6]arene could be used as a starting material for the preparation of calix [6]arenes with two types of modifications at the methylene bridges (Scheme 14).…”

Section: Direct Cà H Functionalization At Meso-position Of Calix[4]an...mentioning

confidence: 99%

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Direct C−H Functionalization of Calix[n](het)arenes (n=4,6): A Brief Update

et al. 2022

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Calix[4]arenes are, probably, the mostly explored macrocycles in the supramolecular chemistry. By means of the synthetic modification/functionalization of the upper or lower rims, as well as meso‐positions, the “host‐guest” properties of these macrocycles can be modulated in order to accommodate the guest molecules of various sizes and nature for supramolecular and coordination chemistry, and to perform various functions for materials science and for biomedical applications. In this review, we wish to highlight the most prospective synthetic approaches for the direct C−H functionalization of calixarene core with various functional moieties. Depending on the nature of the functional moiety these calix[4]arenes can serve as drug carriers and nano‐containers for the recognition, encapsulation or storage of bioactive molecules and for many other applications. Current review article deals with the recent examples of C(H)‐functionalization of calix[4]arenes, as well as selected patterns of direct C(H)‐modification of some calix[6]arenes and calix[4]pyrroles.

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Section: Upper Rim Direct C‐h Functionalizationmentioning

confidence: 99%

Section: Direct Cà H Functionalization At Meso-position Of Calix[4]an...mentioning

confidence: 99%