Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels

Martos, Vera; Bell, Sarah C.; Santos, Eva; Isacoff, Ehud Y.; Trauner, Dirk; Mendoza, Javier de

doi:10.1073/pnas.0813396106

Cited by 54 publications

(35 citation statements)

References 26 publications

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“…Moreover, we must also take into account that this cell growth inhibition might not only be reached by DNA complexation of substituted calixarenes inside tumor cells. Calixarenes are able to self‐assemble inside the cell membrane and alter the membrane potential as well as the ion flux across the double layer 14b. In consideration of this hypothesis, membrane potential measurements along with cell cycle analyses are in progress to shed more light on this aspect 19…”

Section: Resultsmentioning

confidence: 99%

Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides

Hao

Wittlin

2013

Chemistry A European J

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Perhydrolysis of a sterically congested multifunctional epoxide was achieved in ethereal H2O2 with the aid of a recently developed Mo catalyst. The resulting hydroperoxide cyclized to give a 1,2,4-trioxane, which could be readily elaborated into qinghaosu and a range of novel analogues. Some of the compounds with two such trioxane moieties showed in vitro antimalarial activity comparable to or even better than that of artesunate or chloroquine.

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Section: Resultsmentioning

confidence: 99%

Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides

Hao

Wittlin

2013

Chemistry A European J

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“…136 The binding mechanism would be almost the same as TPP-based ligands. The dissociation constant and Hill coefficients were calculated to be several tens of micromolars and ca.…”

Section: View Article Onlinementioning

confidence: 98%

Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

2015

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Chemical sensing of amino acids, peptides, and proteins provides fruitful information to understand their biological functions, as well as to develop the medical and technological applications. To detect amino acids, peptides, and proteins in vitro and in vivo, vast kinds of chemical sensors including small synthetic binders/sensors, genetically-encoded fluorescent proteins and protein-based semisynthetic biosensors have been intensely investigated. This review deals with concepts, strategies, and applications of protein recognition and sensing using small synthetic binders/sensors, which are now actively studied but still in the early stage of investigation. The recognition strategies for peptides and proteins can be divided into three categories: (i) recognition of protein substructures, (ii) protein surface recognition, and (iii) protein sensing through protein-ligand interaction. Here, we overview representative examples of protein recognition and sensing, and discuss biological or diagnostic applications such as potent inhibitors/modulators of protein-protein interactions.

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“…In their work, the authors confirmed with lipid bilayer experiments that 1,3-alt calixarene functions as an artificial transmembrane ion in the presence of Na + , but not K + . Calix [4]arene-based ligands have been shown to be voltage-dependent potassium channels [45]. More recently, chloride transport has been investigated using a calix [4]arene derivative in a DOPC bilayer [46].…”

Section: Cyclodextrins and Calixarenesmentioning

confidence: 99%

Functional Channel Membranes for Drinking Water Production

González‐Pérez

Persson

Lipnizki

2018

Water

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Drinking water production utilities rely on, among other processes, different filtration technologies like bank filtration and slow sand filters, as well as pressure, roughing, or rapid gravity filters that, together with low-and high-pressure operating membranes, help to ensure high quality drinking water for millions of customers all over the world. The global market of membrane separation technologies is projected to reach USD 11.95 Billion by 2021, encompassing water treatment, wastewater treatment, food and beverage processing, industrial gas processing, and pharmaceutical and biomedical applications. In addition to the current, polymer-based membrane separation technologies, new promising strategies using embedded functional motifs, water and ion channels, are expected to play a key role in the next generation of membranes for separation purposes, which are of paramount relevance for drinking water production utilities. In this review, we summarize the different strategies for developing new advanced membranes with a wide variety of functional motifs, like biological and artificial water and ion channels, and their possible impact on drinking water applications.

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Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels

Abstract: Potassium channels are among the core functional elements of life because they underpin essential cellular functions including excitability, homeostasis, and secretion. We present here a series of multivalent calix [

Cited by 54 publications

References 26 publications

Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides

Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides

Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

Functional Channel Membranes for Drinking Water Production

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