Calibration of the Epilepsy Questionnaire for Use in a Low-Resource Setting

Yaria, Joseph; Ogunniyi, Adesola

doi:10.1155/2020/5193189

Cited by 3 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IENT questionnaire needs to be updated according to the new classification of epilepsy. In addition, a semiological support could be added, in order to improve the classification of seizures and epilepsy for health workers in primary care [111].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades

Vergonjeanne¹,

Auditeau²,

Erazo³

et al. 2021

Neuroepidemiology

View full text Add to dashboard Cite

Introduction: Epilepsy affects >50 million people worldwide, with 80% of them living in low- and middle-income countries (LMICs). Studies with a standardized methodology are required to obtain comparable data on epilepsy and implement health policies in order to reduce the treatment gap and improve the diagnosis and management of epilepsy. In 2000, following the guidelines of the International League Against Epilepsy (ILAE), the “questionnaire for investigation of epilepsy in tropical countries” (IENT questionnaire) was developed to promote epidemiological surveys on epilepsy using a standard methodology. This study aims to describe how, when, where, and why the IENT questionnaire has been used through epidemiological studies on epilepsy over the last 2 decades and to acquire users’ opinions about the tool. Methods: Studies that used the IENT questionnaire were searched through international and local bibliographic databases, including the gray literature. An online survey was carried out, including a snowball effect. Original research studies were included. Characteristics of the studies and populations and general information on the instrument and its use were collected. Results: Eighty-two documents were selected referring to 61 studies that were mostly carried out on the African continent (n = 54). Most of them aimed to determine the prevalence (n = 31) and associated factors (n = 28) of epilepsy in LMICs. Among the 61 studies, 35 were population-based, and 30 included both adults and children. A methodological heterogeneity was found between studies, and in cases where the IENT questionnaire alone did not ensure complete data collection, other tools were used concomitantly (n = 40). Discussion/Conclusion: Over the last 2 decades, the IENT questionnaire has been continuously used in different LMICs. This result favors its promotion and updating, with the inclusion of new topics related to epilepsy (e.g., comorbidities, quality of life, and stigma), current ILAE guidelines, and digital versions.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades

Vergonjeanne¹,

Auditeau²,

Erazo³

et al. 2021

Neuroepidemiology

View full text Add to dashboard Cite

show abstract

“…Establishing a tool’s sensitivity, specificity, and predictive value is essential and emphasizes the need for earlier validation [16]. Healthcare providers at the primary and secondary levels of care face many challenges without clinical algorithms or pragmatic rapid diagnostic tests [17]. There may be the need to enforce the widespread use of epilepsy screening questionnaires in primary and secondary healthcare settings to obtain critical information for clinical management and care as a witness.…”

Section: Introductionmentioning

confidence: 99%

Translation and Validation of an Epilepsy Screening Instrument in Two Ghanaian Languages

Darkwa,

Asiamah,

Awini

et al. 2024

Preprint

View full text Add to dashboard Cite

IntroductionThe prevalence of epilepsy in sub-Saharan Africa varies considerably, and the exact estimate in Ghana is unknown, with few data available from peri-urban areas. More community-based studies are required to understand the tangible burden of epilepsy in these areas and the difficulties in healthcare access.ObjectiveTo validate a household survey epilepsy-screening instrument in Shai-Osudoku and Ningo-Prampram District of Greater Accra Region, Ghana.MethodsWe developed a 17-item epilepsy screening instrument by modifying validated English language questionnaires. We included questions that could identify convulsive and non-convulsive seizures. Language experts translated and back-translated the survey instrument into the two languages in this region: Asante Twi and Dangme. Cases were people with epilepsy attending healthcare facilities where these languages are used. Controls were unaffected relatives of cases or people attending the healthcare centres for other medical conditions. We matched cases and controls for geographical location and ethnicity. An affirmative response to one of the seventeen questions was deemed as a positive screen.ResultsOne hundred and Forty Dangme Twi speakers (70 cases and 70 controls) and 100 Twi speakers (50 cases and 50 controls) were recruited. The sensitivity and specificity for Dangme were: Stage 1;100% (95% CI: 88.6, 94.9) and 80% (95% CI: 68.7, 88.6) and Stage 2, 98.6% (95% CI: 92.3, 100.0) and 85.7% (95% CI: 75.3, 92.9). The Dangme version reliably identified epilepsy with positive predictive values of 83.3% (95% CI: 73.6, 90.6) and 87.3% (95% CI: 78.6, 90.6) at stages 1 and 2. The questionnaire excluded epilepsy with negative predictive values of 100% (95% CI: 93.6, 100.0) and 98.4% (95% CI: 91.2, 100.0). For the Twi version, the sensitivity and specificity were: 98% (95% CI: 89.4, 99.9) and 92% (95% CI: 80.8, 97.8) at Stage 1, and for Stage 2, 96% (95% CI: 86.3, 99.5) and 94% (95% CI 83.5, 98.7). The Twi questionnaire reliably specified epilepsy with positive predictive values of 92.5% (95% CI: 81.8%, 97.9) and 94.1% (95% CI: 83.8, 98.8) at stages 1 and 2. It excluded epilepsy with negative predictive values of 97.9% (95% CI: 88.7, 99.9) and 95.9% (95% CI: 86.0, 99.5) for the two-stagesConclusionsOur questionnaire is valid for the two tested languages and is usable for community-based epilepsy surveys in Ghana. The questionnaire can be adapted for other resource-poor settings, although there will need to be translation and iterative in-country testing to ensure its validity is maintained.

show abstract

Advancement in Epilepsy Pharmacotherapy: An Insight into the Pharmacophoric Approaches of Recent Drugs

Sharma,

Kaushik,

Kumar Verma

et al. 2023

CNSAMC

View full text Add to dashboard Cite

Epilepsy is the most general, extensive, and severe neurological disorder, affecting more than 50 million individuals globally. Initially, conventional medicines and simple salts like potassium bromide were employed as antiepileptic medication candidates. Nowadays, many anticonvulsant drugs have been discovered as first-generation and second-generation and newer drugs and are still in development phases. The pharmacophore-based drug design process includes pharmacophore modeling and validation, pharmacophore-based virtual screening, virtual hits profiling, and lead identification with special reference. This comprehensive article reviews recently developed anticonvulsant derivatives on the basis of pharmacophoric approaches. A literature survey was performed using various search engines like Google Scholar, Scopus, Sci Finder, ScienceDirect, Science gate, Scilit, PubMed, NINDS database of NIH, Bentham Sciences, and other online and print journals and scientific databases. The presented review discusses such kinds of newer drugs that are in the market as well as in clinical trial phases. Detailed outcomes of pharmacophoric modeling have been discussed for newly derived derivatives like targets involved in Epilepsy, lead molecules etc., for the treatment of epilepsy. This exhaustive review will assist the researchers in the further development of potential antiepileptic agents.

show abstract

Calibration of the Epilepsy Questionnaire for Use in a Low-Resource Setting

Cited by 3 publications

References 47 publications

Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades

Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades

Translation and Validation of an Epilepsy Screening Instrument in Two Ghanaian Languages

Advancement in Epilepsy Pharmacotherapy: An Insight into the Pharmacophoric Approaches of Recent Drugs

Contact Info

Product

Resources

About