To mathematically predict the behavior of a forward osmosis (FO) process for water recovery, a model was constructed using an asymmetric membrane and glucose as a draw solution, allowing an examination of both phenomenological and process aspects. It was found that the proposed model adequately described the significant physicochemical phenomena that occur in the FO system, including forward water flux, internal concentration polarization (ICP), external concentration polarization (ECP), and reverse solute diffusion (RSD). Model parameters, namely the physiochemical properties of the FO membrane and glucose solutions, were estimated on the basis of experimental and existing data. Through batch FO operations with the estimated parameters, the model was verified. In addition, the influences of ECP and ICP on the water flux of the FO system were investigated at different solute concentrations. Water flux simulation results, which exhibited good agreement with the experimental data, confirmed that ICP, ECP, and RSD had a real impact on water flux and thus must be taken into account in the FO process. With the Latin-hypercube-one-factor-at-a-time (LH-OAT) method, the sensitivity index of diffusivity was at its highest, with a value of more than 40%, which means that diffusivity is the most influential parameter for water flux of the FO system, in particular when dealing with a high-salinity solution. Based on the developed model and sensitivity analysis, the simulation results provide insight into how mass transport affects the performance of an FO system. Several types of membrane-based desalination technology, including electrodialysis, membrane distillation, reverse osmosis (RO), and forward osmosis (FO), have been developed [3,4]. Among these, FO-based water desalination, of which the driving force is an intrinsic osmotic pressure gradient, has a unique position because (1) it is highly resistant to membrane fouling [5], (2) it requires much lower energy [6] and exerts higher driving force than conventional physical separation methods if proper draw solutes are used, and (3) it does not deteriorate the physical properties of feed solution (e.g., color, taste, aroma, and nutrition) [7,8]. For these reasons, FO is viewed as workable especially for difficult feed water with high salinity or foulants. FO can be applied to treat hypersaline streams that are too concentrated for RO [9]. Special cases in which there is no requirement to regenerate draw solution also have high potential, as draw solute: It is possible to use diluted fertilizer for direct fertigation [10][11][12] including wastewater treatment [13] and food concentration [7,8]. One such case is the use of fertilizer.However, there are still many difficult barriers to field implementation of the FO process. Typical problems involve intrinsic, performance-reducing properties, including concentration polarization (CP) and reverse solute diffusion (RSD) [14]. Since both sides of the membrane are in contact with two kinds of solutions, feed solution, and draw s...