Calibration for Elemental Dental Tissue Analysis by Laser Ablation Inductively Coupled Plasma Mass Spectrometry

Miliszkiewicz, Natalia; Walas, Stanisław; Tobiasz, Anna; Kołodziej, Małgorzata; Szostek, Krzysztof

doi:10.1080/00032719.2016.1225305

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…It is linked to ICP-MS capabilities such as large linear response, low limits of detection (µg/mg), and multi elemental analysis [ 21 ]. In addition, when ICP-MS is connected with LA, it may be used for elemental imaging in analyzed samples [ 22 , 23 ]. Application of LA-ICP-MS for analysis of spatial distribution of elements in teeth, may be helpful in to monitored exposition on toxic metals and further incorporation in the body [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The potential of trace elements mapping in child’s natal tooth by laser ablation-ICPMS method

Olszewska

Hańć

2021

J Environ Health Sci Engineer

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Purpose Tooth enamel might provide past chronological metabolic, nutritional status and trace metal exposure during development. Thus, the trace elements distribution embedded in tooth tissues represents an archive of the environmental conditions. The choice of biomarker is estimated as critical to the measurement of metal exposure. Natal teeth are defined as teeth being present at birth. Methods LA-ICP-MS provides a quantitative assessment of spatial distribution of trace elements in a natal tooth. The objective of the current study was to compare concentrations of building and other elements in a rare but reliable and valid biomarker - natal tooth. Results It have been reported presence of potentially toxic elements: Pb, Cu, Mn, Cd, Ni distributed in prenatally and perinatally formed enamel and dentine. Conclusions Analyses of deciduous enamel can provide answers into individuals’ earliest development, including critical pre- and perinatal period.

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Section: Introductionmentioning

confidence: 99%

The potential of trace elements mapping in child’s natal tooth by laser ablation-ICPMS method

Olszewska

Hańć

2021

J Environ Health Sci Engineer

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“…LA-ICP-MSI has been employed to analyse a wide variety of biological tissue, including plant tissue (Callahan et al, 2016), animal tissue (Neumann et al, 2020b), and human tissue samples. In terms of human tissue, some of the most studied samples include brain tissues (Cruz-Alonso et al, 2019), liver tissue samples (Kim et al, 2018), but also MPM tissues (Bonta et al, 2014) or teeth sections (Miliszkiewicz et al, 2017).…”

Section: Introduction To the Chaptermentioning

confidence: 99%

A multimodal approach to identify asbestos and characterise clinically relevant mesothelioma biomarkers

Voloacă¹

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Malignant mesothelioma (MM) is an aggressive cancer of the mesothelium, with long latency and poor overall survival (OS), associated with occupational and environmental exposure to asbestos and other mineral fibres (MF). Considering that early diagnosis has been linked to an improvement in prognosis and treatment response, there is an urgent need for reliable MM biomarkers. Additionally, current asbestos identification techniques lack sensitivity and fail to detect shorter fibres or fibre fragments. Accurately identifying MF within MM samples is not only essential in aiding early diagnosis, but it also plays a key role in linking this diagnosis to asbestos exposure, which has high implications in legal, social, and political matters. The aim of the current project is to (1) develop MM cellular models suitable for laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging, (2) identify various MF based on their metal content within MM in vitro models as well as patient samples using a combination of LA-ICP-MS and LA-ICP-time of flight (TOF)MS instrumentation, (3) investigate the MM metallome in human tissue samples using LA-ICP-MS elemental mapping, and (4) characterise a panel of emerging MM biomarkers using a multi-modal approach. For the first time, this study has developed an asbestos detection technique using LA-ICP-MS imaging to identify MF within MM samples. High-resolution and high-speed analysis suggests that LA-ICP-MS imaging has the potential to be ultimately integrated in the clinical workflow to aid the identification of patients at an earlier and more treatable stage to improve survival outcomes. Moreover, the selected panel of biomarkers was characterised in cellular models, whilst novel biomarkers were tentatively identified using matrix assisted laser desorption ionisation (MALDI)-MS imaging of tissue microarrays, setting the basis for vital future investigations, and ultimately supporting MM biomarker discovery, early diagnosis, and improved prognosis.

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Laser Ablation Microsampling with ICP-MS Detection for Multielemental Bioimaging of Clinical Samples

Ruszczyńska

Wagner

Jagielska

et al. 2022

Handbook of Bioanalytics

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Calibration for Elemental Dental Tissue Analysis by Laser Ablation Inductively Coupled Plasma Mass Spectrometry

Cited by 7 publications

References 47 publications

The potential of trace elements mapping in child’s natal tooth by laser ablation-ICPMS method

The potential of trace elements mapping in child’s natal tooth by laser ablation-ICPMS method

A multimodal approach to identify asbestos and characterise clinically relevant mesothelioma biomarkers

Laser Ablation Microsampling with ICP-MS Detection for Multielemental Bioimaging of Clinical Samples

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