Hydrological models are becoming a fundamental tool for natural resource planning and management; however, their application is hampered by a lack of data for calibration and validation. Therefore, the aim of this study is to calibrate and validate the SWAT model in the Lower Mahanadi River basin. The SWATCUP was used for sensitivity analysis, calibration, and validation of the model. Based on the sensitivity analysis, twelve parameters were calibrated by the SWAT-CUP. The model performance indicators (R2, NSE, and PBIAS) showed satisfactory results with 0.76, 0.78, and 6.6 during calibration and 0.79, 0.74 and 7.8 during validation, respectively