In this article, the combined magneto-hydrodynamic heat, momentum, and mass (species) transfer in external boundary layer flow of Casson nanofluid from a vertical cone surface with convective conditions under an applied magnetic field is studied theoretically. The effects of Brownian motion and thermophoresis are incorporated in the model in the presence of both heat and nanoparticle mass transfer convective conditions. The governing partial differential equations (PDEs) are transformed into highly nonlinear, coupled, multidegree, nonsimilar PDEs consisting of the momentum, energy, and concentration equations via appropriate nonsimilarity transformations. These transformed conservation equations are solved subject to appropriate boundary conditions with a second-order, accurate finite difference method of the implicit type. The influences Nomenclature: A, half angle of the vertical cone; B0, constant magnetic field (Tesla); C, dimensional concentration; Cf, skin friction coefficient; cp, specific heat at constant pressure (J/kg K); DB, Brownian diffusion coefficient (m 2 /s); DT, thermophoretic diffusion coefficient (m 2 /s