Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis
Aranka Brockmueller,
Constanze Buhrmann,
Parviz Shayan
et al.
Abstract:IntroductionOsteoarthritis (OA) is associated with excessive cartilage degradation, inflammation, and decreased autophagy. Insufficient efficacy of conventional monotherapies and poor tissue regeneration due to side effects are just some of the unresolved issues. Our previous research has shown that Calebin A (CA), a component of turmeric (Curcuma longa), has pronounced anti-inflammatory and anti-oxidative effects by modulating various cell signaling pathways. Whether CA protects chondrocytes from degradation … Show more
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