Cálculo coraliforme secundario a topiramato

A, López-Real; Garcia-Antelo, Maria Jose; Fernández-Couto, D.; López-Facal, Soledad; Rubio-Nazabal, Eduardo

doi:10.1016/s1130-6343(08)75952-x

Cited by 2 publications

(3 citation statements)

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“…publications found with both search terms). A total of 72 of them were reviewed in detail, and 47 articles published between 1996 and 2013 were retained for the final analysis, following inclusion of reports found in references (41 in English , five in Spanish and one in German ). They had been reported from following countries: USA ( n = 17), Spain ( n = 5), Great Britain ( n = 4), France ( n = 3), Italy ( n = 3), Brazil ( n = 2), Switzerland ( n = 2), Turkey ( n = 2), Argentina ( n = 1), Australia ( n = 1), Belgium ( n = 1), China ( n = 1), Germany ( n = 1), Hong Kong ( n = 1), Mexico ( n = 1), The Netherlands ( n = 1) and Saudi Arabia ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…Metabolic factors that promote renal stone formation consist of either solute excess or decreased levels of inhibitors of stone formation. Eleven reports , including a total of 84 patients (female:male ratio = 2.9) on medication with topiramate, addressed at least one promoter of stone formation, as shown in Table . Rather discrepant findings were noted with respect to a possible solute excess of calcium and oxalate.…”

Section: Resultsmentioning

confidence: 99%

“…Hypercalciuria 34 31 [20], [23], [24], [46], [47], [49], [54] Hyperoxaluria 15 56 [20], [23], [24], [45], [47], [49] Hyperuricosuria 1 52 [23], [24], [47], [49] Hypocitraturia 67 0 [20], [23], [24], [46], [47], [49], [53], [54] become clinically relevant is undoubtedly essential. Unfortunately, so far no study has addressed the effects of alkali therapy on acid-base and potassium status, urinary citrate excretion and especially the tendency to renal stone formation in patients treated with topiramate.…”

Section: Not Disclosed Referencesmentioning

confidence: 99%

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Metabolic disturbances and renal stone promotion on treatment with topiramate: a systematic review

Dell’Orto

Belotti

Goeggel-Simonetti

et al. 2014

Br J Clin Pharmacol

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AIMSThe use of topiramate, which is prescribed for the management of epilepsy, for migraine headache prophylaxis and as a weight-loss agent, has been associated with the development of metabolic acidosis, hypokalaemia and renal stone disease. We systematically reviewed all the literature. METHODSThe systematic review of the literature was realized using the principles underlying the UK Economic and Social Research Council guidance on the conduct of narrative synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. RESULTSFourty-seven reports published between 1996 and 2013 were retained for the final analysis. Five case-control studies and six longitudinal studies addressed the effect of topiramate on acid-base and potassium balance. A significant tendency towards mild-to-moderate hyperchloraemic metabolic acidosis (with bicarbonate ≤21.0 mmol l −1 in approximately every third case) and mild hypokalaemia (with potassium ≤3.5 mmol l −1 in 10% of the cases) was noted on treatment with topiramate, which was similar in children and adults. A single study observed that topiramate causes mild hyperuricaemia in male adults. A tendency towards hypocitraturia, a recognized promoter of renal stone formation, was noted in all patients on topiramate. CONCLUSIONSIncreasing evidence supports the use of topiramate. Topiramate is generally well tolerated, and serious adverse events are rare. Nonetheless, the present systematic review of the literature indicates that its use is linked with the development of acidosis, hypokalaemia, hyperuricaemia and hypocitraturia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%