Calculations of Radionuclide Organ Retentions from ICRP Biokinetic Recycling Models

Malarbet, J.L.

doi:10.1093/oxfordjournals.rpd.a032431

Cited by 4 publications

(3 citation statements)

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“…The software Cyclomod (Malarbet, 1998) predicts the human urinary and fecal excretion of U and its retention in the compartments of the ICRP models after a given intake. It is based on the biokinetic models of ICRP publications 30, 66 and 69 (ICRP, 1979(ICRP, , 1994(ICRP, , 1995 and the algorithm described by Birchall and James (1987).…”

Section: Biokinetic Models Implementationmentioning

confidence: 99%

The Effect of Repeated Inhalation on the Distribution of Uranium in Rats

Monleau

Blanchardon

Claraz

et al. 2006

Journal of Toxicology and Environmental Health, Part A

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For the assessment of doses after inhalation of airborne uranium compounds by workers, the International Commission on Radiological Protection (ICRP) developed compartmental models that are used to calculate reference dose coefficients and retention and excretion functions. It is assumed that each acute intake has no effect on the biokinetics of later intakes. Consequently, retention and excretion after multiple or chronic exposure are predicted using the same models as after acute exposure. This assumption was tested here on rats exposed to repeated inhalation of uranium dioxide (UO2). First, excretion and organ retention were determined after a single inhalation of UO2. The follow-up of incorporated activity was used to design a biokinetic model for uranium inhaled by rats. Second, the biokinetics of uranium were monitored in two experiments of repeated inhalations of uranium dioxide under different intake patterns. For these two experiments, the organs' retention and excretion after repeated UO2 inhalation were predicted using the biokinetic model and compared to the experimental measurement. Under the two sets of experimental conditions considered, the prediction of the biokinetic model based on acute exposure data was consistent with the biokinetics observed after repeated UO2 inhalations, with the possible exception of retention in the skeleton.

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Section: Biokinetic Models Implementationmentioning

confidence: 99%

The Effect of Repeated Inhalation on the Distribution of Uranium in Rats

Monleau

Blanchardon

Claraz

et al. 2006

Journal of Toxicology and Environmental Health, Part A

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“…The Cyclomod software (Malarbet, 1998) was used to design and implement the biokinetic model of uranium in rats (Monleau et al, in press). Cyclomod predicts human urinary and faecal excretion of uranium and its retention in the ICRP biokinetic model compartments after a given intake.…”

Section: Rat Inhalation Modelmentioning

confidence: 99%

Biokinetic models for rats exposed to repeated inhalation of uranium: implications for the monitoring of nuclear workers

Monleau¹,

Blanchardon²,

Claraz³

et al. 2006

Radioprotection

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“…Sans prétendre être ici exhaustif, on retiendra quelques-uns des axes principaux de ces études : -le dosage de la contamination dans l'eau et la chaîne alimentaire par le laboratoire de Lucien Jeanmaire, en particulier la mesure des transuraniens, d'isotopes du radium et du technétium dans divers matrices organiques (Jeanmaire, 1985) ; -le développement de la mesure de l'exposition interne chez l'homme et d'échantillons de l'environnement par spectrométrie gamma, des isotopes du césium notamment, par le laboratoire de Lucien Jeanmaire et Marie-Louise Daburon (Jeanmaire et al, 1987) ; -l'acquisition des paramètres humains de dépôt et de clairance d'aérosols inhalés sous la responsabilité de Monique Roy et de Jean-Louis Malarbet ; ces études contribuaient à la révision en cours du modèle broncho-pulmonaire de la CIPR (Métivier and Roy, 1999 ;Malarbet, 1998) ; -l'étude de la modélisation de l'exposition interne par Jean Piechowski et Brigitte Menoux, et notamment l'étude des problèmes particuliers de la contamination cutanée et par blessure (Piechowski et al, 1992).…”

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