A mathematical model was developed to simulate two-phase gas-dispersed flow moving through a pipe with axisymmetric sudden expansion. In the model, the two-fluid Euler approach was used. The model is based on solving Reynolds-averaged Navier ⎯ Stokes equations for a two-phase stream. In calculating the fluctuating characteristics of the dispersed phase, equations borrowed from the models by Simonin (1991), , and Derevich (2002) were used. Results of a comparative analysis with previously reported experimental and numerical data on two-phase flows with separation past sudden expansion in a plane channel and in a pipe are given.