Calculation of the blister fluid-time history with ciprofloxacin administered orally or by infusion

Bakhouya, A.; Saïdna, M.; Vergnaud, J.M.

doi:10.1016/s0378-5173(96)04829-6

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…It is possible to calculate the concentration-time histories of ciprofloxacin after taking a controlled-release dosage form, not only in the serum [20][21][22], but also in other parts of the body such as blister fluid [24]. By using the numerical model described in this paper, the concentration-time histories of ciprofloxacin were calculated and drawn in the following places: serum (1), serum-lung tissue interface (2), mean value in the lung tissue (3), lung tissue-bronchial secretion interface (4) and bronchial secretion (5) with dosage forms in which drug release is controlled by erosion.…”

Section: Concentration-time Histories Of Ciprofloxacin In a Controllementioning

confidence: 99%

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Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form

Saïdna¹,

Ouriemchi²,

Vergnaud³

1998

Inflammopharmacol

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The drug level-time history in plasma and lung tissue was calculated with an antibiotic orally delivered in either an immediate-release or a controlled-release dosage form. The drug profiles were compared with experiment results given in the literature. In the same way, the drug level was evaluated in the bronchial secretion in contact with lung tissue. A numerical model, based on finite differences taking all the known facts into account was built and tested with the data found in the literature. Transport of the drug was looked at, including a stage of diffusion through the thickness of the lung tissue and a stage of convection into the bronchial secretion. A few parameters were thus considered, including the thickness of the lung tissue and the diffusivity of the antiobiotic through the tissue, the thickness of the bronchial secretion and the coefficient of convective transport into the sputum which characterizes its viscosity. Two partition factors were also introduced for the drug: between the tissue and the serum and between the lung tissue and the bronchial secretion.

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Section: Concentration-time Histories Of Ciprofloxacin In a Controllementioning

confidence: 99%

“…It is said to be more relevant to measure lung concentration than sputum concentration since the penetration of antibiotics into sputum may be affected by a number of factors [24]. It is difficult to evaluate bronchial secretions because of the occurrence of contamination carried along with blood, saliva and pus [5,6].…”

Section: Introductionmentioning

confidence: 99%

Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form

Saïdna¹,

Ouriemchi²,

Vergnaud³

1998

Inflammopharmacol

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Assessing The Bioavailability of Drug Delivery Systems: Mathematical Modeling

Vergnaud¹,

Rosca

2010

Burger's Medicinal Chemistry and Drug Discovery

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The purpose of this chapter is to describe a method of calculation leading to what it could be called a “quantitative pharmacokinetics,” since the plasma drug profiles are reckoned. This is the answer to the questions set by the U.S. Food and Drug Administration (FDA) in the late 1980s about a possible correlation between the in vivo tests and the in vitro tests for oral dosage forms with controlled release.

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Assessment of blood level with controlled-release dosage forms: Effect of the rate constant of elimination of the drug

Ainaoui¹,

Vergnaud²

1998

Eur. J. Drug Metab. Pharmacokinet.

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Prediction of the drug level in the volume of distribution was made using a numerical model taking into account the following facts: the kinetics of drug release out of the dosage form along the gastrointestinal tract, the kinetics of absorption in the blood compartment and the kinetics of elimination. Various parameters intervene significantly for a given dosage form. Some emphasis was placed upon the rate of elimination of the drug which appears to be the main characteristic for the drug, especially when it is delivered through controlled release dosage forms. The rate of release of the drug out of the dosage form, as well as the dose frequency and the gastrointestinal transit time were also considered. The drug level in the plasma was expressed by the amount of drug as a fraction of the amount of drug initially located in the dosage form.

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Calculation of the blister fluid-time history with ciprofloxacin administered orally or by infusion

Cited by 7 publications

References 14 publications

Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form

Calculation of the antibiotic level in the lung tissue and bronchial secretion with an oral controlled-release dosage form

Assessing The Bioavailability of Drug Delivery Systems: Mathematical Modeling

Assessment of blood level with controlled-release dosage forms: Effect of the rate constant of elimination of the drug

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