Calculation of the antibiotic level in the plasma with an oral erosion-controlled dosage form

Bakhouya, A.; Saïdna, M.; Vergnaud, J.M.

doi:10.1016/s0378-5173(96)04709-6

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…As already shown in previous studies, it is possible to determine the drug level in the blood compartment associated with controlled release dosage forms taken orally (22,23), and the effect of dose frequency appeared to be a significant parameter (24). The previous model has been extended to transfer into the lung tissue with this type of dosage form,…”

Section: Profiles In Blood and Lung Tissue With The Controlled Releasmentioning

confidence: 84%

“…Another approach was developed based on numerical models taking into account all the available data, e.g. the kinetics of drug release in the gastrointestine (01), the stages of absorption in the blood compartment and elimination (22)(23)(24)(25). Following this approach, another numerical model with finite differences was built, taking into account the following stages: drug release in the GI tract, absorption in the blood compartment and elimination, and transient diffusion from the blood compartment into the lung tissue.…”

Section: Assumptionsmentioning

confidence: 99%

“…The controlled release dosage form swells in the gastric fluid; the release kinetics of the drug can be adequately described by Equations 1 and 2 associated with the process of erosion (22). The erosion rate constant Ker =0.0811h.…”

Section: Experimental Protocolsmentioning

confidence: 99%

“…Two kinds of results have been considered: (i) the drug level obtained either in the blood compartment (16,22) or in the lung tissue with an immediate release dosage form taken orally -a comparison is made between the results obtained via experiments and calculation to test the validity of the model and the accuracy of the data; and (ii) the drug level attained not only in the blood compartment but also in the lung tissue with controlled release dosage in multidose form with various regimens.…”

Section: Experimental Protocolsmentioning

confidence: 99%

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Assessment of antibiotic levels in lung tissue with erosion-controlled dosage forms

Saïdna¹,

Ouriemchi²,

Vergnaud³

1997

European Journal of Drug Metabolism and Pharmacokinetics

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The concentration-time curve of ciprofloxacin has been assessed in the blood compartment and in the lung tissue following oral administration of the drug. Immediate release and erosion-controlled dosage forms have been examined. A numerical model based on finite differences and taking into account all relevant data has been built: the kinetics of drug release in the gastrointestinal tract, drug absorption in the blood compartment and elimination, and the transient diffusion of the drug through the lung tissue. A partition coefficient for the drug at the tissue-blood interface has been considered to express the drug concentration at the tissue surface. The effect of dose frequency and erosion rate on the antibiotic versus time curves in the plasma and the lung tissue has been studied in detail.

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Section: Profiles In Blood and Lung Tissue With The Controlled Releasmentioning

confidence: 84%

Section: Assumptionsmentioning

confidence: 99%

Section: Experimental Protocolsmentioning

confidence: 99%

Section: Experimental Protocolsmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of antibiotic levels in lung tissue with erosion-controlled dosage forms

Saïdna¹,

Ouriemchi²,

Vergnaud³

1997

European Journal of Drug Metabolism and Pharmacokinetics

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Assessment of blood level with controlled-release dosage forms: Effect of the rate constant of elimination of the drug

Ainaoui¹,

Vergnaud²

1998

Eur. J. Drug Metab. Pharmacokinet.

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Prediction of the drug level in the volume of distribution was made using a numerical model taking into account the following facts: the kinetics of drug release out of the dosage form along the gastrointestinal tract, the kinetics of absorption in the blood compartment and the kinetics of elimination. Various parameters intervene significantly for a given dosage form. Some emphasis was placed upon the rate of elimination of the drug which appears to be the main characteristic for the drug, especially when it is delivered through controlled release dosage forms. The rate of release of the drug out of the dosage form, as well as the dose frequency and the gastrointestinal transit time were also considered. The drug level in the plasma was expressed by the amount of drug as a fraction of the amount of drug initially located in the dosage form.

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Effect of the nature of the polymer and of the process of drug release (diffusion or erosion) for oral dosage forms

Ainaoui¹,

Vergnaud²

2000

Computational and Theoretical Polymer Science

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Calculation of the antibiotic level in the plasma with an oral erosion-controlled dosage form

Cited by 4 publications

References 10 publications

Assessment of antibiotic levels in lung tissue with erosion-controlled dosage forms

Assessment of antibiotic levels in lung tissue with erosion-controlled dosage forms

Assessment of blood level with controlled-release dosage forms: Effect of the rate constant of elimination of the drug

Effect of the nature of the polymer and of the process of drug release (diffusion or erosion) for oral dosage forms

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