Calculation of serum “total lipid” concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples

Bernert, John T.; Turner, Wayman E.; Patterson, Donald G.; Needham, Larry L.

doi:10.1016/j.chemosphere.2007.02.043

Cited by 217 publications

(122 citation statements)

References 13 publications

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“…The laboratory is approved by the Clinical Laboratory Improvement Amendments and is a member of the CDC reference laboratory network for lipid measurements (Myers et al, 2000). Total serum lipids were calculated using the "short" formula proposed by Phillips et al (1989) and recently validated by the same group (Bernert et al 2007). …”

Section: Study Population and Blood Chemistry Analytic Proceduresmentioning

confidence: 99%

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Гончаров

Haase

Santiago-Rivera

et al. 2008

Environmental Research

165

110

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We have investigated the relationships among the concentration of total serum polychlorinated biphenyls (PCBs), various PCB congener groupings, and three pesticides to total serum lipids in humans with and without self-reported cardiovascular disease. Blood samples were obtained from 335 adult Akwesasne Mohawks, and were analyzed for 101 PCB congeners, mirex, DDE, and hexachlorobenzene (HCB), as well as serum triglycerides and cholesterol. Structural equation modeling, following the definition of latent variables by means of confirmatory factor analysis, was used to analyze the relationships between serum lipids with PCBs and heart disease. There were significant associations among PCBs, lipids, age, and body mass index (BMI), a fact which justified the application of the structural equation model. Gender of the participant was unrelated to any of the remaining study variables. The results of this study are consistent with a model in which age is considered as both an exogenous explanatory variable and a biological driving mechanism for the acquisition of PCBs. Moreover, the results of this study are consistent with the conclusion that PCBs, acting through P450 enzymes, are directly responsible for increased synthesis of cholesterol and triglycerides, substances known to be major risk factors for cardiovascular disease.

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Section: Study Population and Blood Chemistry Analytic Proceduresmentioning

confidence: 99%

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Гончаров

Haase

Santiago-Rivera

et al. 2008

Environmental Research

165

110

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“…Total cholesterol and triglyceride concentrations in cord plasma samples were determined by standard enzymatic procedures (DiaSys Diagnostoc Systems GmbH; Holzheim, Germany) and total lipid concentrations were calculated as described by Bernert et al 2007.…”

Section: Prenatal Exposure To Chlordecone and Other Organochlorine Comentioning

confidence: 99%

Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

Cordier

Bouquet

Warembourg

et al. 2015

Environmental Research

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Background: Perinatal exposure to endocrine-disrupting chemicals may affect thyroid hormones homeostasis and impair brain development. Chlordecone, an organochlorine insecticide widely used in the French West Indies has known estrogenic and progestin properties, but no data is available, human or animal, on its action on thyroid hormone system. Objectives: Our aim was to evaluate the impact of perinatal exposure to chlordecone on the thyroid hormone system of a sample of infants from the Timoun mother-child cohort in Guadeloupe and their further neurodevelopment.Methods: Chlordecone was measured in cord blood and breast milk samples. Thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) were determined in child blood at 3 months (n = 111). Toddlers were further assessed at 18 months using an adapted version of the Ages and Stages Questionnaire (ASQ). Results:Cord chlordecone was associated with an increase in TSH in boys, whereas postnatal exposure was associated with a decrease in FT3 overall, and in FT4 among girls. Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine motor score. Conclusions:Perinatal exposure to chlordecone may affect TSH and thyroid hormone levels at 3 months, differently according to the sex of the infant. This disruption however did not appear to intervene in the pathway between prenatal chlordecone exposure and fine motor child development.

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“…The obtained PCB concentrations were measured in units of pg/g blood; however, PCB concentrations are often expressed in terms of lipid weight because of the lipophilic nature of POPs and the invariability of lipid-adjusted PCB values, regardless of fluctuations in serum lipid levels [19,20]. To correct for the serum total lipid level and obtain the lipid-adjusted PCB value (ng/g lipid), the measured PCB concentration in pg/g blood was divided by the total lipid value, as calculated using the short formula proposed by Phillips et al [19,20] as follows:…”

Section: Blood Sampling and Pcb Congener-specific Analysismentioning

confidence: 99%

“…To correct for the serum total lipid level and obtain the lipid-adjusted PCB value (ng/g lipid), the measured PCB concentration in pg/g blood was divided by the total lipid value, as calculated using the short formula proposed by Phillips et al [19,20] as follows:…”

Section: Blood Sampling and Pcb Congener-specific Analysismentioning

confidence: 99%

Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)

et al. 2011

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Calculation of serum “total lipid” concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples

Cited by 217 publications

References 13 publications

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)

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