Calculation of Glomerular Solute Filtration Rate

Nolph, Karl D.; Maher, John F.

doi:10.1159/000180129

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Inulin was measured in the deproteinized samples according to the method of Bojesen (1952). Glomerular filtration rate was calculated from the clearance of inulin multiplied by the factor 0.95 (Nolph & Maher, 1972); values were expressed as ml min-kg-l.…”

Section: Clearance Measurementsmentioning

confidence: 99%

The Sodium-Retaining Effect of Renal Nerve Activity in the Cat: Role of Angiotensin Formation

1976

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1. The effect of low-frequency stimulation of the renal nerves on renal function and renin release has been investigated. The experiments were performed in unilaterally nephrectomized, anaesthetized cats in which the nerves to the remaining kidney were sectioned. 2. When stimulation frequency was adjusted to reduce renal blood flow by approximately 15% for 15 min, glomerular filtration rate was hardly affected. The ratio sodium clearance/glomerular filtration rate was significantly reduced and plasma renin activity was significantly increased. 3. When the renal nerves were similarly stimulated in the presence of the beta-adrenergic receptor blocking agent, propranolol, the glomerular filtration rate was significantly reduced and the rise in plasma renin activity was significantly inhibited. The reduction of sodium clearance/glomerular filtration rate was as great as in the control animals. 4. The results are consistent with the view that the maintenance of glomerular filtration rate, during renal nerve stimulation which reduced renal blood flow, may be mediated by the local generation of angiotensin. The results also suggest that angiotensin does not play an important role in the sodium retention associated with increased renal nerve activity.

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Section: Clearance Measurementsmentioning

confidence: 99%

The Sodium-Retaining Effect of Renal Nerve Activity in the Cat: Role of Angiotensin Formation

1976

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Effect of peritubular infusion of angiotensin II on rat proximal nephron function

Steven

1974

Kidney International

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Evaluation of the micropuncture determination of single nephron filtration fraction

Jensen¹,

Blaehr²,

Steven³

1984

Kidney International

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Spontaneous and aspirated blood samples were collected from the welling points of surface efferent arterioles in the rat kidney. The amount of tubular reabsorbate in each sample was calculated from measurements of the inulin concentration in the sample and systemic arterial plasma. Both spontaneous and aspirated samples contained substantial amounts of tubular reabsorbate (4% +/- 1% and 11% +/- 1%, respectively). Accordingly, the single nephron filtration fraction values derived from measurements of albumin concentrations alone were significantly lower than those calculated considering the addition of the amount of tubular reabsorbate in each sample (0.26 +/- 0.01 vs. 0.30 +/- 0.01 and 0.25 +/- 0.01 vs. 0.34 +/- 0.01 for the spontaneous and aspirated samples, respectively). Increasing the rate of blood collection from the welling point by aspiration was associated with a significant decrease in the hydraulic pressure in the same vessel. The efferent arteriolar blood samples were therefore probably contaminated with tubular reabsorbate as a result of retrograde flow from the peritubular capillaries. It was confirmed that single nephron filtration fractions derived from hematocrit measurements were significantly higher than those based on albumin concentration measurements, supporting that the hematocrit of afferent arteriolar blood of the superficial nephrons is higher than that of systemic arterial blood.

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Calculation of Glomerular Solute Filtration Rate

Cited by 3 publications

References 4 publications

The Sodium-Retaining Effect of Renal Nerve Activity in the Cat: Role of Angiotensin Formation

The Sodium-Retaining Effect of Renal Nerve Activity in the Cat: Role of Angiotensin Formation

Effect of peritubular infusion of angiotensin II on rat proximal nephron function

Evaluation of the micropuncture determination of single nephron filtration fraction

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