Calculation of Drug Information Necessity Factor of Generic Drugs

Iijima, Hisashi; Kurosaki, Teruyo; Kamei, Miwako; Koshimizu, Toshimasa; Shiragami, Makoto

doi:10.1248/yakushi.123.1039

Cited by 5 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously evaluated information quantities for 15 pharmaceutical ingredients (255 product items) in order to study the present state of generic drug information supply via paper media. 2,3) However, upon determining scores for each piece of information, we found that they did not necessarily re‰ect the necessity of that information in medical care situations. We then conducted a new questionnaire survey of 1,000 medical institutions throughout Japan, revising our evaluation criteria to re‰ect necessity in medical care situations, for the drug information provided.…”

Section: Introductionmentioning

confidence: 86%

“…We then conducted a new questionnaire survey of 1,000 medical institutions throughout Japan, revising our evaluation criteria to re‰ect necessity in medical care situations, for the drug information provided. 4) In this report, we present the results of an objective evaluation of the quantities of generic drug information provided by paper media, based on these new evaluation criteria.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Objective Evaluation of Generic Drug Information

et al. 2004

Self Cite

View full text Add to dashboard Cite

Pharmacists active in health care venues need to be able to evaluate generic drugs in terms of eŠectiveness, safety, and economy to ensure that they are used appropriately. As part of the ongoing study of these factors, we carried out an objective evaluation of information provided for generics. A minimum of 20 commercially available products was considered for each pharmaceutical ingredient. The information subjected to evaluation consisted of the text of drug package inserts and information noted on interview forms. Using our own criteria for evaluating drug information, we attempted to quantify the amounts of information provided. Then, based on the numerical values obtained, we calculated information quantities with reference to drug prices to study the relationship between prices and available information for original drugs and their later-developed, generic equivalents. A total of 14 diŠerent pharmaceutical ingredients (327 product items) were considered, with the information quantity for generics amounting to 27.9±17.8-46.3±21.4％ (Mean± S.D.) that for the original drugs. Examined on the basis of individual pharmaceutical companies, the corresponding ratio came to . For generics, the relationship between drug price (expressed against a value of 1.0 for original drugs) and information quantity (Qua i ) came to 0.79±0.46-1.90±0.79％ (Mean±S.D.). These results clearly point to the importance of evaluating information quantity for generic drugs on a maker-by-maker basis.

show abstract

Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Objective Evaluation of Generic Drug Information

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

Evaluation of Information for Generic Drugs Based on Importance and Necessity

et al. 2005

View full text Add to dashboard Cite

Limited use of generics in Japan has been justiˆed on the basis of problematic quality, distribution and information. Of these three problem areas, the state of provision of information in particular has never been objectively evaluated. We therefore sought to evaluate information according to its necessity and importance to medical practice. To establish criteria for evaluation, we weighted 36 separate pieces of drug information found in package inserts and interview forms according to necessity and importance, based on the results of a survey of nationwide medical institutions with DI o‹ces. We then used the evaluation criteria to evaluate currently available drugs with 20 or more products per formulation. We evaluated 14 formulations (324 products). Generic drugs were found to have 25.3±18.7 to 46.1±14.2 ％ (Mean±S.D.) the information of brand name drugs when products were compared for quantity of information by formulation. However, comparison according to manufacturer returned a larger range of variation at 14.4±8.6 to 64.3 ±14.2％ (Mean±S.D.). These data reveal that manufacturer diŠerences play a large role in the provision of drug information. Drug information was also compared separately by category for both brand name and generic drugs. Generic drugs were found to have insu‹cient information on clinical data, pharmacokinetics, safety, side eŠects, and nonclinical tests. Brand name drugs also scored low points for information on pharmacokinetics. It is imperative that both brand name and generic drugs provide more information on pharmacokinetics.

show abstract

Objective Evaluation of Generic-Specific Drug Information

Iijima

Koshimizu²,

Shiragami³

2007

YAKUGAKU ZASSHI

View full text Add to dashboard Cite

Growth in the use of generic drugs remains flat in Japan, and one of the reasons cited is information availability. We previously showed that the amount of information available on generic drugs differs greatly from one pharmaceutical industry to another, though, on average, it is inferior to that for original, brand name drugs. This report looks at information on individual generic drug products, rather than the active ingredients contained therein. In May 2004, we studied ingredients sold by at least 20 pharmaceutical industries. Here, for the same, particular ingredient, we evaluate current availability of generic-specific information (as of August 2005), as well as change over time. On the basis of ingredient, the amount of information provided for generic drugs is 31.1+/-17.5-57.3+/-11.7% that for the corresponding original drugs (Mean+/-S.D.), but in the company-by-company comparison, a large dispersion of 16.6+/-5.0-69.4+/-11.9% (Mean +/-S.D.) is observed. In terms of information content, generic drugs provided less than 50% as much information on "drug interactions", "clinical efficacy", and "outline of side effects", as that for original drugs. The difference between generic and original drugs was smaller in comparisons focusing on information specific to generics than on those including all drug information. Our study also revealed that, over time, some pharmaceutical industries have added to the amount of information provided. When information is a deciding factor, the quantity available at the current time is not the only relevant aspect; it is best to select a pharmaceutical industry that is proactive about supplementing information post-release.

show abstract

Calculation of Drug Information Necessity Factor of Generic Drugs

Cited by 5 publications

References 2 publications

Objective Evaluation of Generic Drug Information

Objective Evaluation of Generic Drug Information

Evaluation of Information for Generic Drugs Based on Importance and Necessity

Objective Evaluation of Generic-Specific Drug Information

Contact Info

Product

Resources

About