Calculation of beta dosimetry in radiation synovectomy using Monte Carlo simulation (EGS4)

Johnson, L. Scott; Yanch, J. C.

doi:10.1118/1.597028

Cited by 15 publications

(10 citation statements)

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“…227 Beta-particle dosimetry of various radionuclides used in radiation synovectomy, an intraarticular radiation therapy to treat rheumatoid arthritis was also estimated using the EGS4 Monte Carlo code. 228,229 It seems as if we are on the way to a more and more personalized human dosimetry with radiolabeled antibody dosimetry one of the aims. The dose distribution pattern is often calculated by generalizing a point source dose distribution, 230,231 but a direct calculation by Monte Carlo techniques is also frequently reported because it allows media of inhomogeneous density to be considered.…”

Section: E Dosimetry and Treatment Planningmentioning

confidence: 99%

Relevance of accurate Monte Carlo modeling in nuclear medical imaging

1999

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Monte Carlo techniques have become popular in different areas of medical physics with advantage of powerful computing systems. In particular, they have been extensively applied to simulate processes involving random behavior and to quantify physical parameters that are difficult or even impossible to calculate by experimental measurements. Recent nuclear medical imaging innovations such as single-photon emission computed tomography ͑SPECT͒, positron emission tomography ͑PET͒, and multiple emission tomography ͑MET͒ are ideal for Monte Carlo modeling techniques because of the stochastic nature of radiation emission, transport and detection processes. Factors which have contributed to the wider use include improved models of radiation transport processes, the practicality of application with the development of acceleration schemes and the improved speed of computers. In this paper we present a derivation and methodological basis for this approach and critically review their areas of application in nuclear imaging. An overview of existing simulation programs is provided and illustrated with examples of some useful features of such sophisticated tools in connection with common computing facilities and more powerful multiple-processor parallel processing systems. Current and future trends in the field are also discussed.

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Section: E Dosimetry and Treatment Planningmentioning

confidence: 99%

Relevance of accurate Monte Carlo modeling in nuclear medical imaging

1999

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“…28 Some additional applications for radioactive rhenium glass microspheres include treatment of incompletely resected tumors (tumor-bed application), radioembolization of other organs, such as the spleen, 29 and radiation synovectomy treatment of rheumatoid arthritis. 24,30…”

Section: Discussionmentioning

confidence: 99%

“…The absorbed fractions for different radioisotopes and target/source pairs normally are calculated from computer-based Monte Carlo methods, which use probabilistic models to track the interactions and fate of photons or electrons from the time they are emitted from the radioisotope. 23,24 For most situations it is not necessary to calculate S values since the S values for many different sourcetarget organ pairs and radioisotopes are published in the Medical Internal Radiation Dosimetry (MIRD) tables. 25 The S values listed in the MIRD tables have been calculated assuming average physiological conditions and organ sizes.…”

Section: Dosimetric Considerationsmentioning

confidence: 99%

Preparation and properties of radioactive rhenium glass microspheres intended for in vivo radioembolization therapy

Conzone¹,

Häfeli²,

Day³

et al. 1998

J. Biomed. Mater. Res.

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Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO 2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical corrosion tests on microspheres immersed in phosphate-buffered saline (PBS) solution at 37°C. The dosimetric properties of these microspheres also were calculated. The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37°C. Therapeutic radioactive rhenium activities can be obtained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 × 10 13 cm Re could deliver a 100 Gy dose to a cancerous liver while limiting the total body dose from rhenium dissolution in vivo to approximately 1 mGy.

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“…Unter Berücksichti-gung verschiedener, unabhängig erstellter Berechnungen und Näherungen kann als beispielgebende Referenz für eine angenommene Aktivität von 220 MBq 90 Y im Kniegelenk eine an der Synovialisoberfläche wirksame Strahlendosis im Bereich von etwa 40-95 Gy angegeben werden (4,9,22,23,37).…”

Section: Einfu èHrungunclassified