1995
DOI: 10.1016/1056-8719(94)00068-f
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Calculating slope and ED50 of additive dose-response curves, and application of these tabulated parameter values

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Cited by 21 publications
(13 citation statements)
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“…Indeed, the scientific literature contains many publications describing methods for conducting interaction studies. Some examples that provide methodological background include: (Berenbaum 1978(Berenbaum , 1981(Berenbaum , 1984(Berenbaum , 1985(Berenbaum , 1989Carter et al 1979;Carter et al 1984;Carter and Wampler 1986;Caudle and Williams 1993;Chou and Talalay 1984;Gennings 1995Gennings , 1996Gennings et al 1990;Gessner 1995;Greco et al 1995;Greco et al 1990;Loewe and Muischnek 1926;Machado and Robinson 1994;Martinez-Irujo et al 1996;Poch 1980a,b;Poch et al1990a;Poch and Holzmann 1980;Londong 1985, 1993;Poch and Pancheva 1995;Poch et al 1995a. ;Poch et al 1990;Poch et al1990b;Scaramellini et al 1997;Suhnel 1990Suhnel , 1996 200350.pgs 4/13/01, 2:31 PM…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, the scientific literature contains many publications describing methods for conducting interaction studies. Some examples that provide methodological background include: (Berenbaum 1978(Berenbaum , 1981(Berenbaum , 1984(Berenbaum , 1985(Berenbaum , 1989Carter et al 1979;Carter et al 1984;Carter and Wampler 1986;Caudle and Williams 1993;Chou and Talalay 1984;Gennings 1995Gennings , 1996Gennings et al 1990;Gessner 1995;Greco et al 1995;Greco et al 1990;Loewe and Muischnek 1926;Machado and Robinson 1994;Martinez-Irujo et al 1996;Poch 1980a,b;Poch et al1990a;Poch and Holzmann 1980;Londong 1985, 1993;Poch and Pancheva 1995;Poch et al 1995a. ;Poch et al 1990;Poch et al1990b;Scaramellini et al 1997;Suhnel 1990Suhnel , 1996 200350.pgs 4/13/01, 2:31 PM…”
Section: Introductionmentioning
confidence: 99%
“…EC 50 values were obtained from these equations. To measure additive effects of IPI and TCDD or FICZ on EROD we compared the observed effects of the combinations to theoretical best fit curves for additive agonists based on the model of Poch and Pancheva [12]. Statistical comparisons of theoretical and best-fit curves were performed using the extra sum-of-squares F test.…”
Section: Methodsmentioning
confidence: 99%
“…4 In line with our previous in vivo experiments, in vitro cotreatment of heart cells with DFO and PIH analogs had an improved iron-mobilizing effect. To analyze the dose-response profiles of the drug combinations used, we followed the methods described by Poch et al [26][27][28] The use of model combination effects for the delineation of sites and mechanisms of action requires some understanding of the underlying bases of these models. The dose-additivity model describes the combination effects of agents that share the same molecular site of action.…”
Section: Discussionmentioning
confidence: 99%
“…Dose-response profiles of the combination of drugs was subjected to quantitative analysis based on the methods described by Poch et al [26][27][28] Five-day-old cultures were first incubated with 160 M 59 Fe-labeled ferric ammonium citrate for 24 hours, washed, and exposed for another 24 hours to 20 or 40 M DFO and 0 to 160 M 108-o. The effect was described as percentage of initial radioactivity in control iron-loaded cells.…”
Section: Studies In Cultured Heart Cellsmentioning
confidence: 99%
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