Calculating regional tissue volume for hyperthermic isolated limb perfusion: Four methods compared

Cecchin, Diego; Negri, Antonio; Frigo, Anna Chiara; Bui, Franco; Zucchetta, Pietro; Bodanza, Valentina; Gregianin, Michele; Campana, Luca Giovanni; Róssi, Carlo; Rastrelli, Marco

doi:10.1016/j.ejso.2016.02.250

Cited by 7 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Image acquisition parameters included: voltage of 120 kV, X-ray tube current 40–160 mA with an exposure time of 505 ms. In this study, only HUs representing fat in the CT scans were targeted based on the range − 150 to − 50 HU, as defined in previous studies 1 , 4 , 8 . The regions of interest (ROIs) were applied to the patient series when it was processed using VolSEQ to act as a boundary to only quantify pixels in the PSIJ area of the image using pre-made ROIs.…”

Section: Methodsmentioning

confidence: 99%

Fat quantification in the sacroiliac joint syndesmosis: a new semi-automatic volumetric approach

Poilliot,

Zeissloff,

Ondruschka

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Fat is physiologically embedded within the interosseous ligaments in the posterior part of the sacroiliac joint (PSIJ). This composite of fat and ligaments is hypothesized to serve a shock-absorbing, stabilizing function for the sacroiliac joint and the lumbopelvic transition region. Using a novel Python-based software (VolSEQ), total PSIJ volume and fat volume were computed semi-automatically. Differences within the cohort and the viability of the program for the quantification of fat in routine computed tomography (CT) scans were assessed. In 37 CT scans of heathy individuals, the PSIJ were first manually segmented as a region of interest in OSIRIX. Within VolSEQ, ‘fat’ Hounsfield units (− 150 to − 50 HU) are selected and the DICOM file of the patient scan and associated region of interest file from OSIRIX were imported and the pixel sub volumes were then automatically computed. Volume comparisons were made between sexes, sides and ages (≤ 30, 31–64 and > 65 years). PSIJ volumes in both software (VolSeq vs. OSIRIX) were non-different (both 9.7 ± 2.8cm3; p = 0.9). Total PSIJ volume (p = 0.3) and fat volume (p = 0.7) between sexes were non-different. A significant difference in total PSIJ volume between sexes (p < 0.01) but not in fat volume (p = 0.3) was found only in the ≥ 65 years cohort. Fat volume within the PSIJ remains unchanged throughout life. PSIJ volume is sex-dependent after 65 years. VolSEQ is a viable and user-friendly method for sub-volume quantification of tissues in CT.

show abstract

Section: Methodsmentioning

confidence: 99%

Fat quantification in the sacroiliac joint syndesmosis: a new semi-automatic volumetric approach

Poilliot,

Zeissloff,

Ondruschka

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…VolSEQ is intended to help quantify pixels of selected tissue based on a known range of Houns eld units (HU) on conventional CT scans (SOMATOM as64 open, Siemens, Munich, Germany; Aquilion one, Toshiba, Tokyo, Japan). In this study, only HUs representing fat in the CT scans were targeted based on the range − 150 to − 50 HU, as de ned in previous studies 1,4,8 . The regions of interest (ROIs) were applied to the patient series when it was processed using VolSEQ to act as a boundary to only quantify pixels in the PSIJ area of the image using pre-made ROIs.…”

Section: Fat Quanti Cation Using Volseqmentioning

confidence: 99%

“…Quanti cation of tissue volumes and subvolumes using medical imaging techniques is not a new technique [1][2][3][4][5][6][7][8] . Commonly, data sets derived from magnetic resonance imaging (MRI) 2,9−15 or computed tomography (CT) are used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Fat Quantification in the Sacroiliac Joint Syndesmosis- a New Semi-Automatic Volumetric Approach

Poilliot

Zeissloff²,

Ondruschka

et al. 2023

Preprint

View full text Add to dashboard Cite

“…Current hyperthermia strategies generally include local, regional, and whole-body approaches. Several technologies are used, such as microwave, radiofrequency, laser, ultrasound [3] and extracorporeal circulation [4]. For example, intraperitoneal hyperthermic chemotherapy (HIPEC) has been proposed for enhancing the cytotoxic effect of cytostatic drugs on peritoneal malignancies [5].…”

mentioning

confidence: 99%

Technology development of hyperthermic pressurized intraperitoneal aerosol chemotherapy (hPIPAC)

et al. 2021

View full text Add to dashboard Cite

Background Optimized drug delivery systems are needed for intraperitoneal chemotherapy. The aim of this study was to develop a technology for applying pressurized intraperitoneal aerosol chemotherapy (PIPAC) under hyperthermic conditions (hPIPAC). Methods This is an ex-vivo study in an inverted bovine urinary bladder (IBUB). Hyperthermia was established using a modified industry-standard device (Humigard). Two entry and one exit ports were placed. Warm-humid CO2 was insufflated in the IBUB placed in a normothermic bath to simulate body thermal inertia. The temperature of the aerosol, tissue, and water bath was measured in real-time. Results Therapeutic hyperthermia (target tissue temperature 41–43 °C) could be established and maintained over 30 min. In the first phase (insufflation phase), tissue hyperthermia was created by insufflating continuously warm-humid CO2. In the second phase (aerosolization phase), chemotherapeutic drugs were heated up and aerosolized into the IBUB. In a third phase (application phase), hyperthermia was maintained within the therapeutic range using an endoscopic infrared heating device. In a fourth phase, the toxic aerosol was discarded using a closed aerosol waste system (CAWS). Discussion We introduce a simple and effective technology for hPIPAC. hPIPAC is feasible in an ex-vivo model by using a combination of industry-standard medical devices after modification. Potential pharmacological and biological advantages of hPIPAC over PIPAC should now be evaluated.

show abstract

Calculating regional tissue volume for hyperthermic isolated limb perfusion: Four methods compared

Cited by 7 publications

References 17 publications

Fat quantification in the sacroiliac joint syndesmosis: a new semi-automatic volumetric approach

Fat quantification in the sacroiliac joint syndesmosis: a new semi-automatic volumetric approach

Fat Quantification in the Sacroiliac Joint Syndesmosis- a New Semi-Automatic Volumetric Approach

Technology development of hyperthermic pressurized intraperitoneal aerosol chemotherapy (hPIPAC)

Contact Info

Product

Resources

About