Calculating medication compliance, adherence and persistence in administrative pharmacy claims databases

Leslie, Scott R.; Gwadry-Sridhar, Femida; Thiebaud, Patrick; Patel, Bimal V.

doi:10.1179/175709208x334614

Cited by 75 publications

(69 citation statements)

References 4 publications

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“…by guest on May 11, 2018 http://circoutcomes.ahajournals.org/ Downloaded from were shorter than both 60 and 30 days, these 2 permissible gaps were used for persistence calculations. 31,32 Patients who did not discontinue treatment but died, disenrolled from the health plan, or continued therapy beyond the study period were considered censored within the discontinuation analysis.…”

Section: What the Study Addsmentioning

confidence: 99%

Higher Persistence in Newly Diagnosed Nonvalvular Atrial Fibrillation Patients Treated With Dabigatran Versus Warfarin

Zalesak

Siu

Francis

et al. 2013

Circ: Cardiovascular Quality and Outcomes

140

132

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Background-Oral anticoagulation therapy is the primary tool in reducing stroke risk in patients with nonvalvular atrial fibrillation but is underused. Patients nonpersistent with therapy contribute to this underuse. The objective of this study was to compare persistence rates in newly diagnosed nonvalvular atrial fibrillation patients treated with warfarin versus dabigatran as their oral anticoagulation. Methods and Results-US Department of Defense administrative claims were used to identify patients receiving warfarin or dabigatran between October 28, 2010, and June 30, 2012. Patient records were examined for a minimum of 12 months before index date to restrict the analyses to those newly diagnosed with nonvalvular atrial fibrillation and naive-to-treatment, identifying 1775 on warfarin and 3370 on dabigatran. Propensity score matching was used to identify 1745 matched pairs. Persistence was defined as time on therapy to discontinuation. Kaplan-Meier curves were used to depict persistence over time. Cox proportional hazards model was used to determine the factors significantly associated with persistence. Using a 60-day permissible medication gap, the persistence rates were higher for dabigatran than for warfarin at both 6 months (72% versus 53%) and 1 year (63% versus 39%

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Section: What the Study Addsmentioning

confidence: 99%

Higher Persistence in Newly Diagnosed Nonvalvular Atrial Fibrillation Patients Treated With Dabigatran Versus Warfarin

Zalesak

Siu

Francis

et al. 2013

Circ: Cardiovascular Quality and Outcomes

140

132

View full text Add to dashboard Cite

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“…The exact mechanisms of building a PDC report have previously been described. [30][31][32][33][34] One difference in our report is that we used a medication identification number (MedID) to identify similar prescriptions of the same drug, compared with most other PDC calculations, which used generic code numbers (GCN) to identify prescriptions with the same drug and the same or different dose. GCNs are obtained through insurance claims data and are not tracked through internal pharmacy prescription fill records.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Adherence Rates for Antiretroviral, Blood Pressure, or Mental Health Medications for HIV-Positive Patients at an Academic Medical Center Outpatient Pharmacy

Langness¹,

Cook²,

Gill³

et al. 2014

JMCP

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BACKGROUND: Despite advances in safety, tolerability, and decreased pill burden for human immunodeficiency virus (HIV) antiretroviral therapy (ART), nonadherence continues to be a major cause of HIV-related morbidity and mortality. Adherence to these medications presents particular challenges because persons living with HIV (PLWH) must use medication more consistently (≥ 95%) than persons with other chronic diseases, such as hypertension or diabetes mellitus (≥ 80%).

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“…Indirect, methods are based on the assessment of clinical responses by medical professionals, patient questionnaires about adherence, patient diaries, and pill counting. Other types of adherence measurements [3][4][5][6] include medication possession ratio and related measures of medication availability, discontinuation/continuation, switching, medication gaps, refill compliance, and retentiveness/turbulence. A comprehensive list of existing methods is presented in [7].…”

Section: Patient Compliancementioning

confidence: 99%

Impact of ICT on Home Healthcare

Vavilis

Petković

Zannone

2012

ICT Critical Infrastructures and Society

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Abstract. Innovation in information and communication technology has a great potential to create large impact on modern healthcare. However, for the new technologies to be adopted, the innovations have to be meaningful and timely, taking into account user needs and addressing societal and ethical concerns. This paper focuses on ICT innovations related to the home healthcare domain. To ensure the adoption of new healthcare services, the new innovative technologies need to be complemented with new methods that can help patients to establish trust in healthcare service providers in terms of privacy, reliability, integrity of the data chain and techniques that help service providers to assess the reliability of information and data contributed by patients. This paper sketches various lines of research for the development of trusted healthcare services namely, patient compliance, reliability of information in healthcare, and userfriendly access control.

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Calculating medication compliance, adherence and persistence in administrative pharmacy claims databases

Cited by 75 publications

References 4 publications

Higher Persistence in Newly Diagnosed Nonvalvular Atrial Fibrillation Patients Treated With Dabigatran Versus Warfarin

Higher Persistence in Newly Diagnosed Nonvalvular Atrial Fibrillation Patients Treated With Dabigatran Versus Warfarin

Comparison of Adherence Rates for Antiretroviral, Blood Pressure, or Mental Health Medications for HIV-Positive Patients at an Academic Medical Center Outpatient Pharmacy

Impact of ICT on Home Healthcare

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