Calculating limits of detection and defining working ranges for multi-signal calibration methods

Abstract

<p>Error propagation used to calculate LODs for MEC and MICal in MIP OES, ICP OES and ICP-MS determinations. Best trueness and precisions found for 0.1 &lt; calibration slope &lt; 0.9.</p>

Introducing multi-energy ratios as an alternative to multi-energy calibration for Br determination via high-resolution continuum source graphite furnace molecular absorption spectrometry. A case study

“…In conclusion, while Virgilio et al recommended using slope values between 0.1 and 0.9 for MIP OES, ICP OES and ICP-MS, 24 it seems advisable to limit this range more and use values between 0.5 and 0.6 in the case of monitoring CaBr using HR CS GFMAS for both MEC and MER strategies to guarantee a well-balanced relation between accuracy and precision. seem to show linearity in other ranges, 33 from 120 or 200 to 400 ng and probably more, but notice that such linearities (e.g., from 200 to 400 for pixels 131, 114 and 100) do not necessarily go through the intercept.…”

“…This effect will be further discussed in Section 3.2. Virgilio et al 24 recently shown experimentally that use of "extreme conditions" for the slope (≤0.1 or ≥0.9) results in lower trueness.…”

“…Very recently, Virgilio et al have proposed a method for calculating LOD/LOQ for multi-signal calibrations, including MEC. 24 The authors use equation 13 to calculate the LOD/LOQ, where is the standard deviation of the MEC slope, and N is 3 when calculating the LOD, and 10 for the LOQ. Thus, this strategy was also investigated, and the results are shown in Table 4.…”

“…considering Slope = 0. The first strategy is similar to the one proposed by Virgilio et al 24 The second uses equation 13 with the minimum number of different transitions recommended for a MEC analysis, which is three, as discussed by Donati & Amais. 3 The third and fourth ones are estimations based on the following concept.…”

Graphene oxide-derived carbonaceous sensor: turn-off fluorescence sensor for nanomolar detection of ruthenium ions in aqueous medium

“…The LOD value was calculated from the Stern-Volmer plot using the standard formula (3s/k), where 's' is the concentration of Ru(III) and 'k' is the slope obtained from the Stern-Volmer plot. 81 Using the above equation, the LOD of the GOPND probe was calculated as 15 nM. The sensing ability of the GOPND towards Ru(III) through fluorescence quenching is rationalized by proposing a mechanism based on literature reports.…”