Calculated plasma osmolality at hospital admission correlates well with eGFR and D-Dimer, a simple outcome predictor and guiding tool for management of severe COVID-19 patients

Ramesh, J.; Rajesh, M; Varghese, Johann; Reddy, Sarah

doi:10.1016/j.dsx.2021.102240

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Keparahan. 2 Rumah Sakit Palang Merah Wuhan di China meneliti pasien Diabetes dari 24 Januari hingga 15 Maret. Kasus-kasus dibagi menjadi kelompok diabetes dan nondiabetes sesuai dengan riwayat mengambil obat antidiabetes atau dengan plasma puasa kadar glukosa darah saat masuk, dan perbedaan antara kelompok dibandingkan.…”

Section: Pendahuluanunclassified

Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat

Yulia¹,

Rikarni²,

Nasrul³

2022

Heme

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Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh berjemur dan pemberian tablet kalsium terhadap kadar D-dimer pada penderita Diabetes Mellitus tipe 2 yang terkontrol. Berjemur adalah memanfaatkan sarana alam sinar matahari yang tersedia sesuai standar operasional waktu yang terukur, dan pemberian tablet Kalsium 500 mg tiap hari dapat menurunkan kadar D-dimer yang berisiko terjadinya obstruksi pada pembuluh darah dan berpotensi munculnya kerusakan endotel pembuluh darah. Dengan menggunakan faktor alam terapi berjemur dapat membantu memperbaiki penyakit dan merencanakan terapi. Metode: Rancangan penelitian ini adalah studi kohort prospektif dengan jumlah sampel sebanyak 20 data pasien yang terdiagnosis sebagai penderita Diabetes Mellitus tipe 2 di RSUD Prof Dr. Ali Hanafiah SM Batusangkar selama periode 2019-2020. Data yang dianalisis adalah kadar D-dimer sebelum dilakukan perlakuan berjemur dengan waktu yang terukur, serta pemberian tablet kalsium sebagai suplemen yang dapat mempengaruhi proses koagulasi dalam pembuluh darah. Kasus Diabetes mellitus tipe 2 dipilih kasus Diabetes yang terkontrol dengan pemeriksaan HBA1c dibawah 6.5%. Selajutnya, setelah dilakukan proses berjemur dan pemberian suplemen Kalsium selama 1 bulan, dilakukan kembali pemeriksaan D-dimer. Analisis data penelitian dilakukan pada derajat kepercayaan 95% CI (α=0.05), apabila hasil yang didapatkan diperoleh nilai p<0.05 maka terdapat hubungan yang bermakna. Pengolahan dan analisis data dilakukan dengan program SPSS 25. Hasil: Dua puluh pasien Diabetes Mellitus tipe 2 dilakukan pemerisaan D-dimer didapatkan rerata d-dimer 582 ±806 ng/mL. Selanjutnya dilakukan perlakuan berjemur sesuai protokol berjemur selama 30 hari dan pemberian suplemen tablet kalsium 500 mg, setelah itu dilakukan kembali pemeriksaan kadar D-dimer, didapatkan rerata d-dimer 401 ±390 ng/mL Terdapat kecenderungan penurunan kadar D-dimer setelah perlakuan berjemur dan pemberian tablet kalsium dengan hubungan yang bermakna antara kadar D-dimer sebelum dan sesudah perlakuan berjemur dan pemberian tablet kalsium pada penderita Diabetes Mellitus tipe 2. Simpulan: Pada penelitian ini ditemukan penurunan kadar D-dimer pada pasien Diabetes Mellitus tipe 2 setelah dilakukan perlakuan berjemur dan pemberian tablet kalsium. Namun, tidak diketahui apakah peran kombinasi berjemur dengan pemberian tablet kalsium atau ada peran dari masing masing variabel.

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Section: Pendahuluanunclassified

Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat

Yulia¹,

Rikarni²,

Nasrul³

2022

Heme

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Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis

Schlesinger,

Lang,

Christodoulou

et al. 2023

Diabetologia

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Aims/hypothesis To provide a systematic overview of the current body of evidence on high-risk phenotypes of diabetes associated with COVID-19 severity and death. Methods This is the first update of our recently published living systematic review and meta-analysis. Observational studies investigating phenotypes in individuals with diabetes and confirmed SARS-CoV-2 infection with regard to COVID-19-related death and severity were included. The literature search was conducted from inception up to 14 February 2022 in PubMed, Epistemonikos, Web of Science and the COVID-19 Research Database and updated using PubMed alert to 1 December 2022. A random-effects meta-analysis was used to calculate summary relative risks (SRRs) with 95% CIs. The risk of bias was evaluated using the Quality in Prognosis Studies (QUIPS) tool and the certainty of evidence using the GRADE approach. Results A total of 169 articles (147 new studies) based on approximately 900,000 individuals were included. We conducted 177 meta-analyses (83 on COVID-19-related death and 94 on COVID-19 severity). Certainty of evidence was strengthened for associations between male sex, older age, blood glucose level at admission, chronic insulin use, chronic metformin use (inversely) and pre-existing comorbidities (CVD, chronic kidney disease, chronic obstructive pulmonary disease) and COVID-19-related death. New evidence with moderate to high certainty emerged for the association between obesity (SRR [95% CI] 1.18 [1.04, 1.34], n=21 studies), HbA1c (53–75 mmol/mol [7–9%]: 1.18 [1.06, 1.32], n=8), chronic glucagon-like peptide-1 receptor agonist use (0.83 [0.71, 0.97], n=9), pre-existing heart failure (1.33 [1.21, 1.47], n=14), pre-existing liver disease (1.40 [1.17, 1.67], n=6), the Charlson index (per 1 unit increase: 1.33 [1.13, 1.57], n=2), high levels of C-reactive protein (per 5 mg/l increase: 1.07 [1.02, 1.12], n=10), aspartate aminotransferase level (per 5 U/l increase: 1.28 [1.06, 1.54], n=5), eGFR (per 10 ml/min per 1.73 m2 increase: 0.80 [0.71, 0.90], n=6), lactate dehydrogenase level (per 10 U/l increase: 1.03 [1.01, 1.04], n=7) and lymphocyte count (per 1×109/l increase: 0.59 [0.40, 0.86], n=6) and COVID-19-related death. Similar associations were observed between risk phenotypes of diabetes and severity of COVID-19, with some new evidence on existing COVID-19 vaccination status (0.32 [0.26, 0.38], n=3), pre-existing hypertension (1.23 [1.14, 1.33], n=49), neuropathy and cancer, and high IL-6 levels. A limitation of this study is that the included studies are observational in nature and residual or unmeasured confounding cannot be ruled out. Conclusions/interpretation Individuals with a more severe course of diabetes and pre-existing comorbidities had a poorer prognosis of COVID-19 than individuals with a milder course of the disease. Registration PROSPERO registration no. CRD42020193692. Previous version This is a living systematic review and meta-analysis. The previous version can be found at https://link.springer.com/article/10.1007/s00125-021-05458-8 Funding The German Diabetes Center (DDZ) is funded by the German Federal Ministry of Health and the Ministry of Culture and Science of the State North Rhine-Westphalia. This study was supported in part by a grant from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (DZD). Graphical Abstract

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Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes

Lucijanic,

Krecak,

Cicic

et al. 2023

Scandinavian Journal of Clinical and Laboratory Investigation

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Calculated plasma osmolality at hospital admission correlates well with eGFR and D-Dimer, a simple outcome predictor and guiding tool for management of severe COVID-19 patients

Cited by 3 publications

References 37 publications

Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat

Efek Pemberian Kalsium dan Berjemur Terhadap Kadar D-Dimer pada Penderita Diabetes Mellitus Tipe 2 di Sumatera Barat

Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis

Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes

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