CALCRL knockdown suppresses cancer stemness and chemoresistance in acute myeloid leukemia with FLT3‐ITD and DNM3TA‐R882 double mutations
Shanhao Tang,
Huiling Zhu,
Lixia Sheng
et al.
Abstract:Acute myeloid leukemia (AML) patients with FLT3 internal tandem duplication (FLT3‐ITD) and DNA methyltransferase 3A (DNMT3A) R882 double mutations had a worse prognosis compared with AML with FLT3‐ITD or DNMT3A R882 single mutation. This study was designed to explore the specific role of Calcitonin Receptor Like (CALCRL) in AML with FLT3‐ITD and DNMT3A R882 double mutations. MOLM13 cells were transduced with CRISPR knockout sgRNA constructs to establish the FTL3‐ITD and DNMT3A‐R882 double‐mutated AML cell mode… Show more
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