Calcium uptake, release and ryanodine binding in melanosomes from retinal pigment epithelium

Salceda, Rocı́o; Sánchez‐Chávez, Gustavo

doi:10.1054/ceca.2000.0111

Cited by 51 publications

(45 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(51) It has been suggested that melanosomes regulate calcium concentration within the retinal pigment epithelium. (52) Further, Ca 2þ released from the lumen of mammalian endocytic compartments and lysosomes mediates membrane fusion and efficient membrane trafficking in the endocytic pathway, (28,53) (56,57) and calcium carbonate containing inner ear otoliths in mocha, muted and pallid.…”

Section: Platelet Dense Granulesmentioning

confidence: 99%

Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles

et al. 2004

View full text Add to dashboard Cite

In the mouse, at least 16 genes regulate vesicle trafficking to specialized lysosome-related organelles, including platelet dense granules and melanosomes. Fourteen of these genes have been identified by positional cloning. All 16 mouse mutants are models for the genetically heterogeneous human disease, Hermansky-Pudlak Syndrome (HPS). Five HPS genes encode known vesicle trafficking proteins. Nine genes are novel, are found only in higher eukaryotes and encode members of three protein complexes termed BLOCs (Biogenesis of Lysosome-related Organelles Complexes). Mutations in murine HPS genes, which encode protein co-members of BLOCs, produce essentially identical phenotypes. In addition to their well-known effects on pigmentation, platelet function and lysosome secretion, HPS genes control a wide range of physiological processes including immune recognition, neuronal functions and lung surfactant trafficking. Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS.

show abstract

Section: Platelet Dense Granulesmentioning

confidence: 99%

Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles

et al. 2004

View full text Add to dashboard Cite

show abstract

“…More importantly, RPE cells were found to take up Ca 2+ [45]. Moreover, Ca 2+ uptake was found to be dependent on the degree of pigmentation of the RPE [46], and further studies showed Ca 2+ uptake and release by melanosomes (see, e.g., [47]). …”

Section: Figmentioning

confidence: 99%

Comparison of visual function in pigmented and albino rats by electroretinography and visual evoked potentials

Heiduschka

Schraermeyer

2008

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…exchanger has been proposed. Such activity has been measured in isolated melanosomes from retinal pigment epithelial cells [314] and large dense core granules in PC12 cells [309]. In the latter cell type, however, as well as in many other cells, our group failed to measure a DH ?…”

Section: Acidic Compartmentsmentioning

confidence: 91%

“…Additionally, caffeine (a pharmacological activator of RyRs) was shown to mediate Ca 2? release from isolated melanosomes [314]. But the most potent Ca 2?…”

Section: Acidic Compartmentsmentioning

confidence: 99%

Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?

Zampese

Pizzo

2011

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

An increase in the concentration of cytosolic free Ca(2+) is a key component regulating different cellular processes ranging from egg fertilization, active secretion and movement, to cell differentiation and death. The multitude of phenomena modulated by Ca(2+), however, do not simply rely on increases/decreases in its concentration, but also on specific timing, shape and sub-cellular localization of its signals that, combined together, provide a huge versatility in Ca(2+) signaling. Intracellular organelles and their Ca(2+) handling machineries exert key roles in this complex and precise mechanism, and this review will try to depict a map of Ca(2+) routes inside cells, highlighting the uniqueness of the different Ca(2+) toolkit components and the complexity of the interactions between them.

show abstract

Calcium uptake, release and ryanodine binding in melanosomes from retinal pigment epithelium

Cited by 51 publications

References 31 publications

Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles

Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles

Comparison of visual function in pigmented and albino rats by electroretinography and visual evoked potentials

Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?

Contact Info

Product

Resources

About