Calcium uptake in rat liver mitochondria accompanied by activation of ATP-dependent potassium channel

Акопова, О. В.; Nosar, V. I.; Mankovskaya, I. N.; Сагач, В. Ф.

doi:10.1134/s000629790810012x

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…(55) In turn, the mechanisms of dissociation of oxidative phosphorylation and activation of free oxidation, providing thermogenesis, are controlled by a system of calcium homeostasis. (56,57) The impact of a strong stress factor leads to a decrease in the calciumtransport function of mitochondria, as a result of which the energy deficit of cells and tissues increases. (58) It is well known that low temperatures contribute to reduction of skin microcirculation, redistribution of blood flow, and reduction of systolic pressure.…”

Section: Basic Partmentioning

confidence: 99%

Effects of Low Temperatures on the Formation of Adaptive Reactions: A Review

Patrakeeva¹,

Basova²

2018

IJBM

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Section: Basic Partmentioning

confidence: 99%

Effects of Low Temperatures on the Formation of Adaptive Reactions: A Review

Patrakeeva¹,

Basova²

2018

IJBM

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“…Энергетические возможности органов с импульс-ным характером функционирования (сердце, мыш-цы) отличаются от органов с постоянным уровнем фунциональной активности (печень, мозг) [1,11,12,54]. Интенсивность окисления митохондриями эндогенных субстратов определяется тканевой при-надлежностью, в частности, в наших исследованиях эндогенное дыхание в почке контрольных животных оказалось на 60 % выше, чем в митохондриях ткани печени (табл.…”

Section: результаты исследованияunclassified

“…След-ствием этого является нарушение трансформации энергии в различные формы (АТФ, Г ТФ, ∆µ H, ∆µ ψ и др.) [1,7,11,12] и развитие низкоэнергетического сдвига или биоэнергетической гипоксии.…”

Section: результаты исследованияunclassified

“…[7,18]. Метаболизм печени можно отнести к окислительному типу [1,11,12]. Основным энергетическим субстратом для печени также являются жирные кислоты, энергетический метаболизм которых осуществляется исключитель-но за счет окисления в митохондриях.…”

Section: результаты исследованияunclassified

“…Очевидно, что вследствие митохондри-альной дисфункции нарушается работа ряда насо-сов (Na [1,15,31,48]. Неблагоприятные биоэнергетические эф-фекты вибрации явились причиной морфологиче-ских изменений: нарастания дистрофии тканей, уменьшения капиллярной сети, спазма артериол, увеличения межклеточного отека, постепенного расширения очагов кровоизлияний и некроза.…”

Section: результаты исследованияunclassified

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Tissue specific peculiarities of vibration-induced hypoxia of the rabbit heart, liver and kidney

Vorobieva

Shabanov

2016

Rev Clin Pharm Drug Ther

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kKeyword:vibration; mitochondria; energy metabolism; heart; liver; kidney; vibration model of hypoxia; dystrophy; rabbit. AAdsoras:The purpose of the paper was experimental study of activity of energy production of the heart, liver and kidney after harmful action of general vibration with 8 and 44 Hz frequency. The functional state of native mitochondria in tissue homogenates was studied by polarographic method by means of closed oxygen device of halvanic type in thermostated cuvette of 1 ml volume in the salt medium of incubation. Metabolic states of mitochondria of the rabbit heart, liver and kidney were modeled in vitro in oxidation of endogenous substrates (before and after administration of inhibitors of different stages of breath chain) varying exogenous substrates (before and after administration of 2.4-DNP into the cell). In order to synchronize the changes in short time, the incomplete cycle of metabolic states "endogenous breath → rest → activity" was used. The velocity of mitochondrial oxidation of endogenous substrates was determined by tissue

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Influence of ATP-dependent K+-channel opener on K+-cycle and oxygen consumption in rat liver mitochondria

Акопова

Nosar

Bouryi

et al. 2010

Biochemistry Moscow

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The influence of the K+(ATP)-channel opener diazoxide on the K+ cycle and oxygen consumption has been studied in rat liver mitochondria. It was found that diazoxide activates the K+(ATP)-channel in the range of nanomolar concentrations (50-300 nM, K(1/2) ~ 140 nM), which results in activation of K+/H+ exchange in mitochondria. The latter, in turn, accelerates mitochondrial respiration in respiratory state 2. The contribution of K+(ATP)-channel to the mitochondrial potassium cycle was estimated using the selective K+(ATP)-channel blocker glibenclamide. The data show that the relative contribution of K+(ATP)-channel in the potassium cycle of mitochondria is variable and increases only with the decrease in the ATP-independent component of K+ uptake. Possible mechanisms underlying the observed phenomena are discussed. The experimental results more fully elucidate the role of K+(ATP)-channel in the regulation of mitochondrial functions, especially under pathological conditions accompanied by impairment of the mitochondrial energy state.

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Calcium uptake in rat liver mitochondria accompanied by activation of ATP-dependent potassium channel

Cited by 5 publications

References 19 publications

Effects of Low Temperatures on the Formation of Adaptive Reactions: A Review

Effects of Low Temperatures on the Formation of Adaptive Reactions: A Review

Tissue specific peculiarities of vibration-induced hypoxia of the rabbit heart, liver and kidney

Influence of ATP-dependent K+-channel opener on K+-cycle and oxygen consumption in rat liver mitochondria

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