Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients

Rozen, Paul; Lubin, Flora; Papo, Naomi; Knaani, Judith; Farbstein, Hanan; Farbstein, Motti; Zajicek, G.

doi:10.1002/1097-0142(20010215)91:4<833::aid-cncr1071>3.0.co;2-9

Cited by 26 publications

(8 citation statements)

References 28 publications

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“…The findings from several smaller controlled studies were inconsistent, with some suggesting decreases in the LI and/or φ h , and other studies indicating no change or statistically non-significant increases in the LI and/or φ h . The results of the present study for the LI are consistent with those from the previously conducted large clinical trials (13, 14); and for the φ h with one large clinical trial (13) and several smaller clinical trials (reviewed in (22), also (42, 43)). However, it must be emphasized that the present study was a pilot study with limited statistical power; thus, our findings may have been due to chance.…”

Section: Discussionsupporting

confidence: 91%

Effects of Vitamin D and Calcium on Proliferation and Differentiation In Normal Colon Mucosa: a Randomized Clinical Trial

Fedirko

Bostick

Flanders

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

109

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To investigate the potential efficacy of calcium and vitamin D in reducing risk for colorectal neoplasms and to develop "treatable" phenotypic biomarkers of risk for colorectal neoplasms, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial to test the effects of these agents on cell cycle markers in the normal colorectal mucosa. Ninetytwo men and women with at least one pathologyconfirmed colorectal adenoma were treated with 2 g/day calcium and/or 800 IU/day vitamin D 3 versus placebo over 6 months. Overall expression and distributions of p21 waf1/cip1 (marker of differentiation), MIB-1 (marker of short-term proliferation), and hTERT (marker of long-term proliferation) in colorectal crypts in the normal-appearing rectal mucosa were detected by automated immunohistochemistry and quantified by image analysis. In the calcium, vitamin D, and calcium plus vitamin D groups relative to the placebo, p21 expression increased by 201% (P = 0.03), 242% (P = 0.005), and 25% (P = 0.47), respectively, along the full lengths of colorectal crypts after 6 months of treatment. There were no statistically significant changes in the expression of either MIB-1 or hTERT in the crypts overall; however, the proportion of hTERT, but not MIB-1, expression that extended into the upper 40% of the crypts was reduced by 15% (P = 0.02) in the vitamin D plus calcium group relative to the placebo. These results indicate that calcium and vitamin D promote colorectal epithelial cell differentiation and may "normalize" the colorectal crypt proliferative zone in sporadic adenoma patients, and support further investigation of calcium and vitamin D as chemopreventive agents against colorectal neoplasms. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2933-41)

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Section: Discussionsupporting

confidence: 91%

Effects of Vitamin D and Calcium on Proliferation and Differentiation In Normal Colon Mucosa: a Randomized Clinical Trial

Fedirko

Bostick

Flanders

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

109

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“…A randomized trial of calcium and antioxidant vitamins on 77 patients operated on for colorectal cancer showed that calcium and vitamin supplementation does not reduce cell kinetics of the colon (Cascinu et al, 2000). Only a small, 1 y trial of calcium supplementation found a significant suppression of rectal epithelial cell proliferation levels in the intervention group (Rozen et al, 2001).…”

Section: Calciummentioning

confidence: 99%

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003

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Objectives: This review provides an overview of the principal hypotheses and epidemiological evidence of the possible links between colorectal cancer and intake of milk and=or dairy products. Methods: The first section outlines the main hypotheses about the possible effect of calcium, vitamin D, fats and other milk components. The possible role of acid lactic bateria in fermented products is also discussed. The second section is a summary of the published epidemiological evidence. The results on milk, cheese and yoghurt are summarized using a meta-analytical approach. The results of studies on calcium and vitamin D are briefly described. Results: Case -control studies are heterogeneous and, on average, do not provide evidence of association between total intake of total dairy products, milk, cheese or yoghurt and colorectal cancer risk. The average result from cohort studies support the hypothesis of a protective effect of total dairy products (odds ratio (OR): 0.62; 95% confidence interval (CI): 0.52 -0.74; P heterogeneity test: 0.93) and for milk (OR: 0.80; 95% CI: 0.68 -0.95; P heterogeneity: 0.77). No association was found between cheese (OR: 1.10; 95% CI: 0.88 -1.36; P heterogeneity: 0.55) or yoghurt (OR: 1.03; 95% CI: 0.83 -1.28; P heterogeneity: 0.69) in cohort studies. Conclusions: Cohort studies consistently found a protective effect of total dairy products and milk intake, but the evidence is not supported by case -control studies. No relationship was found with cheese or yoghurt intake. As the number of cohort studies is still limited, their results need to be confirmed by other prospective studies.

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“…For the relationship between calcium and CRC risk, the Egyptian [ 43 ] and Israelian [ 44 ] studies found that calcium is a protective factor. For the Egyptian study, calcium rich diet was considered as a protective factor with OR = 0.08 (95% CI: 0.04–0.17).…”

Section: Resultsmentioning

confidence: 99%

“…The major limit of the Israelian study [ 44 ], even if it’s a prospective study, was the low number of voluntary participants, alongside with the large proportion of intervened patients who did not finish the 1 year of calcium intervention and non-intervened patients who did not comply with the 1 year rectal biopsy. This study may lack of power and its results may not apply in a similar situation.…”

Section: Discussionmentioning

confidence: 99%

Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review

et al. 2018

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BackgroundThis systematic review was conducted to explain the association between dairy products and colorectal cancer (CRC) risk in Middle Eastern and North African countries (MENA).MethodsThe database consulted were PubMed, Clinical Trials, and Cochrane to extract the relevant studies published till the 31stof December 2016, using inclusion and exclusion criteria according to Prisma Protocol. The characteristics of these studies comprised the consumption of all types of dairy products in relation to CRC risk.ResultsSeven studies were included in this review. For dairy products overall, no significant association was found. Regarding modern dairy products, included studies found controversial results with OR = 9.88 (95% CI: 3.80–24.65) and ORa = 0.14 (95% CI: 0.02–0.71). A positive association was reported between traditional dairy products and CRC risk, to OR = 18.66 (95% CI: 3.06–113.86) to OR = 24 (95% CI: 1.74–330.82) to ORa = 1.42 (95% CI: 0.62–3.25), ptrend = 0.03. Calcium was inversely associated with the CRC risk with ORa = 0.08 (95% CI: 0.04–0.17).ConclusionThis is the first systematic review which illustrated the association between dairy consumption and CRC risk in MENA region. The results were inconsistent and not always homogeneous. Further specified studies may be warranted to address the questions about the association between CRC and dairy products in a specific context of MENA region.

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Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients

Cited by 26 publications

References 28 publications

Effects of Vitamin D and Calcium on Proliferation and Differentiation In Normal Colon Mucosa: a Randomized Clinical Trial

Effects of Vitamin D and Calcium on Proliferation and Differentiation In Normal Colon Mucosa: a Randomized Clinical Trial

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review

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