Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Buppasiri, Pranom; Lumbiganon, Pisake; Thinkhamrop, Jadsada; Ngamjarus, Chetta; Laopaiboon, Malinee; Medley, Nancy

doi:10.1002/14651858.cd007079.pub3

Cited by 83 publications

(41 citation statements)

References 71 publications

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“…Systematic reviews of studies on the effect of maternal calcium supplementation on several pregnancy and infant outcomes concluded that calcium supplementation has no significant effect on infant length and HC but resulted in a small increase (65-80 g) in birth weight (30)(31)(32), supporting the hypothesis that calcium 2 P values refer to the comparison between the calcium plus vitamin D and placebo groups by using ANCOVA after adjusting for significant covariates. 3 Factors tested in the overall group by using multiple linear regression models for measurements at birth were ppBMI, dietary calcium intake during pregnancy, maternal supplementation may increase somatic fetal growth.…”

Section: Discussionmentioning

confidence: 95%

“…3 Factors tested in the overall group by using multiple linear regression models for measurements at birth were ppBMI, dietary calcium intake during pregnancy, maternal supplementation may increase somatic fetal growth. However, the clinical significance of this small effect on birth weight was considered uncertain (30,31). In fact, no effect on infant birth weight, length, and HC were observed in randomized controlled maternal calcium supplementation trials in different populations (6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

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Calcium Plus Vitamin D Supplementation During the Third Trimester of Pregnancy in Adolescents Accustomed to Low Calcium Diets Does Not Affect Infant Bone Mass at Early Lactation in a Randomized Controlled Trial ,

Diogenes

Bezerra

Rezende

et al. 2015

The Journal of Nutrition

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Calcium and vitamin D supplementation of the adolescents studied resulted in higher fetal body weight at 36 wk of gestation and had no effect on infant bone mass at 5 wk postpartum. Because correlations between maternal and infant bone mass were evident only in the placebo group, infant bone mass appeared to be more dependent on maternal skeletal mass when calcium intake was low. This trial was registered at clinicaltrials.gov as NCT01732328.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Calcium Plus Vitamin D Supplementation During the Third Trimester of Pregnancy in Adolescents Accustomed to Low Calcium Diets Does Not Affect Infant Bone Mass at Early Lactation in a Randomized Controlled Trial ,

Diogenes

Bezerra

Rezende

et al. 2015

The Journal of Nutrition

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“…Twenty-one reviews reported on LBW, 24-44 11 on SGA 29 31-33 35-39 45 46 and 3 reviews on IUGR. 28 45 46 Two studies reported VLBW 30 32 while none of the included reviews reported ELBW. Twenty-two studies assessed the effect of the interventions on PTB.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…30 The number of included participants in the reviews ranged from 603 participants 41 to over 310 000 participants. 24 Supplementation with vitamins was reported in five reviews, 24-26 45 46 supplementation with minerals in eight reviews [27][28][29][30][31][32][33][34] and MMN supplementation was assessed in three reviews. [35][36][37] There was one review on protein supplementation and nutritional education 38 and two reviews reported on marine oil and fatty acid supplementation.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

et al. 2017

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IntroductionLow birth weight (LBW, birth weight less than 2500 g) is associated with infant mortality and childhood morbidity. Poor maternal nutritional status is one of several contributing factors to LBW. We systematically reviewed the evidence for nutrition-specific (addressing the immediate determinants of nutrition) and nutrition-sensitive (addressing the underlying cause of undernutrition) interventions to reduce the risk of LBW and/or its components: preterm birth (PTB) and small-for-gestational age (SGA).MethodsWe conducted a comprehensive literature search in MEDLINE, EMBASE, CINAHL and the Cochrane Database of Systematic Reviews (September 2015). Systematic reviews of randomised controlled trials focusing on nutritional interventions before and during pregnancy to reduce LBW and its components were eligible for inclusion into the overview review. We assessed the methodological quality of the included reviews using A Measurement Tool to Assess Reviews (AMSTAR), PROSPERO: CRD42015024814.ResultsWe included 23 systematic reviews which comprised 34 comparisons. Sixteen reviews were of high methodological quality, six of moderate and only one review of low quality. Six interventions were associated with a decreased risk of LBW: oral supplementation with (1) vitamin A, (2) low-dose calcium, (3) zinc, (4) multiple micronutrients (MMN), nutritional education and provision of preventive antimalarials. MMN and balanced protein/energy supplementation had a positive effect on SGA, while high protein supplementation increased the risk of SGA. High-dose calcium, zinc or long-chain n-3 fatty acid supplementation and nutritional education decreased the risk of PTB.ConclusionImproving women’s nutritional status positively affected LBW, SGA and PTB. Based on current evidence, especially MMN supplementation and preventive antimalarial drugs during pregnancy may be considered for policy and practice. However, for most interventions evidence was derived from a small number of trials and/or participants. There is a need to further explore the evidence of nutrition-specific and nutrition-sensitive interventions in order to reach the WHO’s goal of a 30% reduction in the global rate of LBW by 2025.

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Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews

Ota

Lopes

Middleton

et al. 2020

Cochrane Database of Systematic Reviews

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Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Cited by 83 publications

References 71 publications

Calcium Plus Vitamin D Supplementation During the Third Trimester of Pregnancy in Adolescents Accustomed to Low Calcium Diets Does Not Affect Infant Bone Mass at Early Lactation in a Randomized Controlled Trial ,

Calcium Plus Vitamin D Supplementation During the Third Trimester of Pregnancy in Adolescents Accustomed to Low Calcium Diets Does Not Affect Infant Bone Mass at Early Lactation in a Randomized Controlled Trial ,

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews

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