Calcium supplementation for prevention of primary hypertension

Cormick, Gabriela; Ciapponi, Agustín; Cafferata, María Luisa; Belizán, José M.

doi:10.1002/14651858.cd010037.pub2

Cited by 91 publications

(91 citation statements)

References 64 publications

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“…Higher levels of parathyroid hormone and DHVD stimulate calcium influx into different cell types and increase intracellular calcium into the vascular smooth muscle cell, and consequently increased muscle reactivity, peripheral vascular resistance, and thus higher blood pressure. 18,19 In order to effectively implement the WHO recommendations and reduce the risk of hypertensive disorders of pregnancy in the most vulnerable women, it is essential to identify the specific populations or subpopulations at higher risk. This would allow the evidence-based priorisation of calcium supplementation, and would inform the development of policies, strategies, and actions, including a population-specific quantity assessment of the additional calcium intake required.…”

Section: Introductionmentioning

confidence: 99%

Global inequities in dietary calcium intake during pregnancy: a systematic review and meta‐analysis

Cormick

Betrán

Romero

et al. 2018

BJOG

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Background Evidence shows that adequate calcium intake during pregnancy reduces the risk of hypertensive disorders of pregnancy. In most low‐ and middle‐income countries ( LMIC s) the daily calcium intake is well below recommendations. Mapping calcium intake during pregnancy worldwide and identifying populations with low calcium intake will provide the evidence base for more targeted actions to improve calcium intake. Objective To assess dietary calcium intake during pregnancy worldwide. Search strategy MEDLINE and EMBASE (from July 2004 to November 2017). Selection criteria Cross‐sectional, cohort, and intervention studies reporting calcium intake during pregnancy. Data collection and analysis Five reviewers working in pairs independently performed screening, extraction, and quality assessment. We reported summary measures of calcium intake and calculated the weighted arithmetic mean for high‐income countries ( HIC s) and LMIC s independently, and for geographic regions, among studies reporting country of recruitment, mean intake, and total number of participants. When available, inadequate intakes were reported. Main results From 1880 citations 105 works met the inclusion criteria, providing data for 73 958 women in 37 countries. The mean calcium intake was 948.3 mg/day (95% CI 872.1–1024.4 mg/day) for HIC s and 647.6 mg/day (95% CI 568.7–726.5 mg/day) for LMIC s. Calcium intakes below 800 mg/day were reported in five (29%) countries from HIC s and in 14 (82%) countries from LMIC s. Conclusion These results are consistent with a lack of improvement in calcium dietary intake during pregnancy and confirm the gap between HIC s and LMIC s, with alarmingly low intakes recorded for pregnant women in LMIC s. From the public health perspective, in the absence of specific local data, calcium supplementation of pregnant women in these countries should be universal. Tweetable abstract Despite dietary recommendations, women in LMIC s face pregnancy with diets low in calcium.

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Section: Introductionmentioning

confidence: 99%

Global inequities in dietary calcium intake during pregnancy: a systematic review and meta‐analysis

Cormick

Betrán

Romero

et al. 2018

BJOG

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“…On the other hand, according to Bucher et al [37], a high intake of calcium in subjects with high adherence to the DASH diet may act as a modulating factor of BP levels, specifically decreasing systolic BP, although this speculation remains controversial. In their review of randomized clinical trials, Cormick et al [38] indicated that abundant calcium intake slightly reduced systolic BP and diastolic BP, especially in normotensive young adults. On the other hand, a higher intake of fruits, vegetables, and legumes, together with less SFA and more monounsaturated fatty acid consumption, may explain the beneficial effects of the DASH diet on the parameters of abdominal fat and visceral fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

Stricter Adherence to Dietary Approaches to Stop Hypertension (DASH) and Its Association with Lower Blood Pressure, Visceral Fat, and Waist Circumference in University Students

et al. 2020

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How diet affects blood pressure (BP) in young adults has not been studied in sufficient depth. For this purpose, we analyzed adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and BP in Spanish university students. The sample population of our cross-sectional study consisted of 244 subjects (18-31 years old), who were in good health. Measurements were taken of their systolic and diastolic BP. A food frequency questionnaire and 72 h food record were used to assess their dietary intake in the previous year. The resulting DASH score was based on foodstuffs that were emphasized or minimized in the DASH diet. Analysis of covariance adjusted for potential confounding factors showed that the mean values for systolic BP, visceral fat rating, and waist circumference (WC) of the subjects in the upper third of the DASH score were significantly lower than those of the subjects in the lower third (for systolic BP: mean difference −4.36 mmHg, p = 0.004; for visceral fat rating: mean difference −0.4, p = 0.024; for waist circumference: mean difference −3.2, p = 0.019). Stricter adherence to the DASH dietary pattern led to a lower BP, visceral fat rating, and WC values in these university students. Nevertheless, further prospective studies are needed to confirm these results.

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“…38 The authors of the most recent meta-analysis, published in 2015, analyzed the results of 16 clinical trials (n=3048) with exclusively normotensive subjects. 39 Once again, a modest yet significant effect was found (SBP mean difference [MD] −1.43 mmHg, 95% CI −2.15 to −0.72; DBP MD −0.98 mmHg, 95% CI −1.46 to −0.50). The mechanism by which calcium may reduce BP has not been confirmed; however, it has been suggested that when adequate amounts of calcium are consumed, the entry of calcium into cells is inhibited and as a consequence vasoconstriction is attenuated.…”

Section: Black Cumin Seeds (Nigella Sativa)mentioning

confidence: 95%

An Integrative Approach to Hypertension: A Comprehensive Review of Antihypertensive Nutrients and Botanicals

Adams¹,

González²,

Miranda-Massari³

et al. 2016

j restorat med

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Objective:We conducted a comprehensive review of the most current data available on the antihypertensive effects of 29 different nutraceuticals. Design:In this review, we collected evidence from clinical trials and meta-analyses of clinical trials with human subjects that are representative of the general adult population; studies of infants, children, and pregnant women were excluded. Observational studies were included in some cases as supplementary evidence, and in vitro or animal studies were included only for the purpose of explaining hypotensive mechanisms. PubMed served as the primary search engine. Outcome measures:The efficacy of each nutrient and botanical was demonstrated by a treatment that resulted in a reduction of either systolic or diastolic blood pressure in humans. Results:All of the reviewed botanical and nutrient supplements, with the exception of French maritime pine bark extract and maitake (Grifola frondosa), have been demonstrated to effectively lower blood pressure in humans with good tolerability.Conclusions: Current data supporting the use of nutrients and botanicals in the treatment of blood pressure are encouraging.

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Calcium supplementation for prevention of primary hypertension

Abstract: Calcium supplementation for prevention of primary hypertension.

Cited by 91 publications

References 64 publications

Global inequities in dietary calcium intake during pregnancy: a systematic review and meta‐analysis

Global inequities in dietary calcium intake during pregnancy: a systematic review and meta‐analysis

Stricter Adherence to Dietary Approaches to Stop Hypertension (DASH) and Its Association with Lower Blood Pressure, Visceral Fat, and Waist Circumference in University Students

An Integrative Approach to Hypertension: A Comprehensive Review of Antihypertensive Nutrients and Botanicals

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