Calcium Silicate/Chitosan-Coated Electrospun Poly (Lactic Acid) Fibers for Bone Tissue Engineering

Su, Chu-Jung; Tu, Ming-Gene; Wei, Li-Ju; Hsu, Tuan-Ti; Kao, Chia‐Tze; Chen, Tsui-Han; Huang, Tsui‐Hsien

doi:10.3390/ma10050501

Cited by 28 publications

(16 citation statements)

References 44 publications

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“…Wettability plays a key role in determining the biological behavior of a biomaterial, and thus is a critical factor when designing biomaterials 30 . Cellular behaviors were enhanced when cells were grown on specimens with a water contact angle that was lower than 75° 31 . Our data further indicated that gelatin-BVSM materials were hydrophilic 32 .…”

Section: Discussionmentioning

confidence: 99%

Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

Shie

Lin

et al. 2017

Sci Rep

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In our previous study, we found that gelatin-based materials exhibit good conductivity and are non-cytotoxic. In this study, gelatin was cross-linked with bisvinyl sulfonemethyl (BVSM) to fabricate a biodegradable conduit for peripheral nerve repair. First, BVSM on the prepared conduit was characterized to determine its mechanical properties and contact angle. The maximum tensile strength and water contact angle of the gelatin-BVSM conduits were 23 ± 4.8 MPa and 74.7 ± 9°, which provided sufficient mechanical strength to resist muscular contraction; additionally, the surface was hydrophilic. Cytotoxicity and apoptosis assays using Schwann cells demonstrated that the gelatin-BVSM conduits are non-cytotoxic. Next, we examined the neuronal electrophysiology, animal behavior, neuronal connectivity, macrophage infiltration, calcitonin gene-related peptide localization and expression, as well as the expression levels of nerve regeneration-related proteins. The number of fluorogold-labelled cells and histological analysis of the gelatin-BVSM nerve conduits was similar to that observed with the clinical use of silicone rubber conduits after 8 weeks of repair. Therefore, our results demonstrate that gelatin-BVSM conduits are promising substrates for application as bioengineered grafts for nerve tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

Shie

Lin

et al. 2017

Sci Rep

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“…Altering manufacturing parameters makes it possible for stimulating natural tissues with tailored biological characteristics appropriate for the recovery of tissues. The advantages of CS are actually broadly described; among the major positive aspects of CS, one can mention the capability to modify properties such as the degradation rate by altering the degree of deacetylation and it's Mw [157][158][159][160][161][162][163][164][165][166][167][168]. Additive components are regularly incorporated into CS in an effort to enhance its printability, fidelity, or to fabricate new cell-laden matrices.…”

Section: Benefits Limitations and Future Prospectsmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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“…It is observed that the zein/HA membranes can support cell proliferation and shows promise in bone tissue engineering applications. Su et al [148] studied the secretion levels of Collagen I and fibronectin on electrospun PLA NFs coated by calcium silicate. They found that using inorganic apatite coatings tend to make suitable conditions for bone tissue engineering.…”

Section: Applications Of Ceramic Electrospun Matsmentioning

confidence: 99%

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

2017

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Ceramic nanofibers (NFs) have recently been developed for advanced applications due to their unique properties. In this article, we review developments in electrospun ceramic NFs with regard to their fabrication process, properties, and applications. We find that surface activity of electrospun ceramic NFs is improved by post pyrolysis, hydrothermal, and carbothermal processes. Also, when combined with another surface modification methods, electrospun ceramic NFs result in the advancement of properties and widening of the application domains. With the decrease in diameter and length of a fiber, many properties of fibrous materials are modified; characteristics of such ceramic NFs are different from their wide and long (bulk) counterparts. In this article, electrospun ceramic NFs are reviewed with an emphasis on their applications as catalysts, membranes, sensors, biomaterials, fuel cells, batteries, supercapacitors, energy harvesting systems, electric and magnetic parts, conductive wires, and wearable electronic textiles. Furthermore, properties of ceramic nanofibers, which enable the above applications, and techniques to characterize them are briefly outlined.

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Calcium Silicate/Chitosan-Coated Electrospun Poly (Lactic Acid) Fibers for Bone Tissue Engineering

Cited by 28 publications

References 44 publications

Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

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