Calcium signaling in neuroglia

Lim, Dmitry; Semyanov, Alexey; Genazzani, Armando A.; Verkhratsky, Alexei

doi:10.1016/bs.ircmb.2021.01.003

Cited by 49 publications

(45 citation statements)

References 303 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Astrocytes respond to neurochemical stimulation associated with neuronal activity with a transient increase in cytosolic ion concentrations, which are the basis for astrocytic excitability [ 27 ]. In particular, intracellular signals mediated by Ca 2+ and Na + regulate homeostatic responses of astrocytes aimed at supporting neuronal function [ 28 , 29 ]. Astrocytic contribution to the pathophysiology of all neurological diseases may be primary, when changes in astrocytes drive neuropathology; examples may include Alexander disease or psychiatric disorders associated with substantial astrocytic atrophy.…”

Section: Astrocytes: Homeostatic and Protective Arm Of The Central Ne...mentioning

confidence: 99%

Astrocytes in Post-traumatic Stress Disorder

Zhang

Verkhratsky

2022

Neurosci. Bull.

Self Cite

View full text Add to dashboard Cite

Although posttraumatic stress disorder (PTSD) is on the rise, traumatic events and their consequences are often hidden or minimized by patients for reasons linked to PTSD itself. Traumatic experiences can be broadly classified into mental stress (MS) and traumatic brain injury (TBI), but the cellular mechanisms of MS- or TBI-induced PTSD remain unknown. Recent evidence has shown that the morphological remodeling of astrocytes accompanies and arguably contributes to fearful memories and stress-related disorders. In this review, we summarize the roles of astrocytes in the pathogenesis of MS-PTSD and TBI-PTSD. Astrocytes synthesize and secrete neurotrophic, pro- and anti-inflammatory factors and regulate the microenvironment of the nervous tissue through metabolic pathways, ionostatic control, and homeostatic clearance of neurotransmitters. Stress or trauma-associated impairment of these vital astrocytic functions contribute to the pathophysiological evolution of PTSD and may present therapeutic targets.

show abstract

Section: Astrocytes: Homeostatic and Protective Arm Of The Central Ne...mentioning

confidence: 99%

Astrocytes in Post-traumatic Stress Disorder

Zhang

Verkhratsky

2022

Neurosci. Bull.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, an antagonist of the InsP3 pathway, wortmannin, prevents neurogenesis in neural crest cells (Evrard et al, 2004 ). In addition, Ca 2+ waves propagate through radial glial cells in the proliferative cortical ventricular zone (VZ) and require connexin hemichannels, P2Y1 ATP receptors, and intracellular InsP3-mediated Ca 2+ release, suggesting critical roles for radial glial signaling mechanisms in cortical neuronal production (Weissman et al, 2004 ; Lim et al, 2021b ). In this process, the G protein-coupled receptor GPR157, an orphan G protein-coupled receptor, is involved in regulating the neuronal differentiation of radial glial progenitors through Gq-InsP3-mediated Ca 2+ cascades (Takeo et al, 2016 ).…”

Section: Ca 2+ Inhibits the Regulation Of Neuronal Stem Cellsmentioning

confidence: 99%

Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits

Guan

Cao

Yang

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (APs) and neurofibrillary tangles (NFTs). Although calcium ions (Ca2+) promote the formation of APs and NFTs, no systematic review of the mechanisms by which Ca2+ affects the development and progression of AD has been published. Therefore, the current review aimed to fill the gaps between elevated Ca2+ levels and the pathogenesis of AD. Specifically, we mainly focus on the molecular mechanisms by which Ca2+ affects the neuronal networks of neuroinflammation, neuronal injury, neurogenesis, neurotoxicity, neuroprotection, and autophagy. Furthermore, the roles of Ca2+ transporters located in the cell membrane, endoplasmic reticulum (ER), mitochondria and lysosome in mediating the effects of Ca2+ on activating neuronal networks that ultimately contribute to the development and progression of AD are discussed. Finally, the drug candidates derived from herbs used as food or seasoning in Chinese daily life are summarized to provide a theoretical basis for improving the clinical treatment of AD.

show abstract

“…Homeostatic support, provided by astrocytes, is of paramount importance for proper brain functioning [1]. During continuous interaction with neurons in the central nervous system (CNS), astrocytes generate intracellular calcium (Ca 2+ ) signals which are thought to mediate their homeostatic activities, including release of signalling molecules, control of cerebral blood flow, regulation of K + and neurotransmitter uptake and control of neuronal activity [2,3]. Moreover, deregulation of astrocytic Ca 2+ signals and downstream signalling processes are strongly associated with neuropathologies including Alzheimer's disease and epilepsy [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, deregulation of astrocytic Ca 2+ signals and downstream signalling processes are strongly associated with neuropathologies including Alzheimer's disease and epilepsy [4,5,6]. Much effort has been devoted to detection and characterization of astroglial Ca 2+ signals themselves [7,8], while how the Ca 2+ signals in astrocytes are decoded, processed and translated to arrange a multitude of astroglial homeostatic activities is poorly understood [3].…”

Section: Introductionmentioning

confidence: 99%