Calcium Sensor for Photoacoustic Imaging

Roberts, Sheryl; Seeger, Markus; Jiang, Yuanyuan; Mishra, Anurag; Sigmund, Felix; Stelzl, Anja; Lauri, Antonella; Symvoulidis, Panagiotis; Rolbieski, Hannes; Preller, Matthias; Deán‐Ben, Xosé Luís; Razansky, Daniel; Orschmann, Tanja; Desbordes, Sabrina C.; Vetschera, Paul; Bach, Thorsten; Ntziachristos, Vasilis; Westmeyer, Gil G.

doi:10.1021/jacs.7b03064

Cited by 120 publications

(104 citation statements)

References 21 publications

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“…PA imaging has been researched for sensing of heavy‐metal ions, including copper (Cu 2+ ), methylmercury (MeHg + ), mercury(II), calcium (Ca 2+ ), lithium (Li + ), and silver (Ag + ) . For example, Chan and co‐workers developed two acoustogenic PA probes (APC‐1 and APC‐2) for the sensing of Cu 2+ .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…Compounds 2 , 3 , and 4 showed no detectable fluorescence. The weak or absent NIR fluorescence of BPcs should be favorable for photoacoustic (PA) imaging, which is a increasingly popular imaging modality that can provide three‐dimensional images with real‐time correlation, clinically relevant depths, and relatively high spatial resolution using non‐ionizing radiation ,–. It is desirable to use non‐emissive molecules, since PA imaging is based on the detection of ultrasonic waves generated by photothermal expansion, which is derived from the non‐radiative process.…”

Section: Methodsmentioning

confidence: 99%

Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform

et al. 2019

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Near-infrared (NIR) imaging techniques have attracted significant attention for biological and medicinal applications due to the ability of NIR to penetrate deeply into tissues.H owever,t here are very few stable,a ctivatable molecular probes that can utilize NIR light in the wavelength range beyond 800 nm. Herein, we report an ew activatable NIR system for photoacoustic imaging based on tautomeric benziphthalocyanines (BPcs). We found that the existence of afree hydroxyl group is crucial for NIR absorption of BPcs. Synthesized water-soluble hydroxy BPcs exhibited high photostability and no fluorescence,w hicha re desirable features for photoacoustic imaging. We synthesized BPcs in which the free hydroxyl group was masked by an esterase-labile or an H 2 O 2labile group.T he photoacoustic signals of these hydroxymasked BPcs were increased upon NIR excitation at 880 nm in the presence of esterase or H 2 O 2 ,r espectively.T hese are rare examples of activatable probes utilizing NIR light at around 900 nm.

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“…However, the addition of ethylenediaminetetraacetic acid (EDTA) (80 × 10 −6 m ) restored the PA signal to that of the metal‐free probe by chelating and removing Ca 2+ . Subsequently, they also reported the cell‐permeable and selective Ca 2+ probe (denoted as CaSPA_550) in Figure a, which was synthesized by a reaction between 3‐ethyl‐1,1,2‐trimethyl‐1H‐benzo[e]indol3‐ium iodide and the appropriate aldehyde of a 1,2‐bis(2‐aminophenoxy)ethane N , N , N ′, N ′‐tetraacetate skeleton. As the concentration of Ca 2+ increased from 0–39 × 10 −6 m , there was a reduction of CasPA_550's absorbance peak at 550 nm, with the appearance of a minor blue‐shifted absorbance peak at 455 nm (Figure b).…”

Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Zeng

Lin

et al. 2018

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Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.

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Calcium Sensor for Photoacoustic Imaging

Cited by 120 publications

References 21 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

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