Calcium Sensing Receptor Gene A986S Polymorphism and Responsiveness to Calcium Supplementation in Postmenopausal Women

Abstract

Recently several studies in adolescent girls or premenopausal women have implicated the calcium sensing receptor (CASR) gene A986S polymorphism in calcium and bone metabolism. However, the role of this genetic variant in postmenopausal women, specifically the development of osteoporosis, is unknown. This study reports the findings of a randomized, double-blind, placebo-controlled study of healthy postmenopausal women followed for 2 yr while taking placebo or supplementary calcium. Specifically, we examined the relationship between the CASR A986S polymorphism, bone biochemical profile, and bone mineral density at baseline and after 2 yr of treatment. We found no effect of this genetic variant in postmenopausal women at baseline or in response to calcium supplementation. These results are in contrast to those in young or premenopausal women, and they provide no support for an important role for the CASR A986S polymorphism in osteoporosis.

Serum calcium, urine calcium and polymorphisms of the calcium sensing receptor gene

“…4%, 24.8% and 0.8%, respectively) individuals in the West of Scotland appears to be comparable with studies in other Caucasian populations, e.g. Canadian (70.5%, 26.4% and 3.1%), 2 New Zealand (71.6%, 23.5% and 4.9%) 5 and Swedish (71.1%, 25.8% and 3.1%). 6 These studies show the A986S polymorphism to be the most prevalent variant in Caucasian populations.…”

Vitamin D Receptor and Calcium-Sensing Receptor Gene Polymorphisms in Hypercalciuric Stone-Forming Patients

“…With respect to CaSR polymorphisms, association with serum calcium have been reported in some studies [12,36,67,68] but not in all of them [39,47,48,69]. Few studies focused on the association of CaSR with urinary calcium in calcium-stone-forming patients [38,42].…”

“…Nevertheless, only a few of these studies had been conducted in calcium-stone-forming patients [38,42]. Association with BMD was detected by some investigators [45,46] but not by others [43,47,48,49]. …”

Associations of Vitamin D Receptor, Calcium-Sensing Receptor and Parathyroid Hormone Gene Polymorphisms with Calcium Homeostasis and Peripheral Bone Density in Adult Finns

“…The non-conservative Ala 986 Ser ( A986S ) polymorphism in the CaSR gene has been shown to associate with serum calcium and urinary calcium (U-Ca) excretion [14][15][16][17][18] . However, some evidence is contradictory [19][20][21][22] , and the association with BMD is less definite [22][23][24] . The overall effect of PTH is to raise serum calcium concentrations by regulating the synthesis of calcitriol and the reabsorption of calcium in the kidney.…”